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Beginner Puzzle: T-cell Lymphoma Invasion Protein

Status: Closed

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24	krulon 140 7459	foldeRNA	10,288	78
25	Fat Tony 140 2424	foldeRNA	10,288	77

Comments

Mon, 03/21/2011 - 04:29

#1

infjamc 140 2101

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Joined: 02/20/2009

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Does this structure feature a chain break again?

The backbone of residues #11-12 look strange...

Mon, 03/21/2011 - 05:39

#2

beta_helix 140 3540

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Joined: 05/09/2008

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yes

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).

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