Beginner Puzzle: T-cell Lymphoma Invasion Protein

Summary

Name:

Status:

Closed

Created:

03/20/2011

Points:

100

Difficulty:

Intermediate

Description:

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?

Categories:

Rank

Group

Score

Points

Void Crushers

10,351

100

10,339

10,335

10,288

10,253

Rank

Player

Group

Score

Points

TheGUmmer 56 56

Void Crushers

10,351

100

10,350

10,350

10,339

CharlieFortsCon... 82 110

Contenders

10,338

Rank

Player

Group

Score

Points

spmm 135 2177

Void Crushers

10,344

100

10,324

10,323

10,307

10,302

Mon, 03/21/2011 - 04:29

infjamc 135 1899

Offline

Joined: 02/20/2009

Groups: Contenders

Does this structure feature a chain break again?

The backbone of residues #11-12 look strange...

Mon, 03/21/2011 - 05:39

beta_helix 135 3196

Offline

Joined: 05/09/2008

Groups: None

yes

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).