Contest Info

Name: Pregnancy Associated Plasma Protein (PAPP-A)
Owner: meschruhms
Start Date: 03/12/11
End Date: 08/15/11
Puzzle: Freestyle Design: Variable Length
Description:

(From Wikipedia)
Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome.[1][2]

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes).[2] For example, low PAPPA may be seen in prenatal screening for Down syndrome.[1]

At the University of Wisconsin: Steven's Point, the research team i'm affiliated with is further studying the pathways, properties, and implications of PAPP-A. Any help, or just being able to include this protein in the program for demonstration would be much appreciated.


Registered Contestants

UserScoresort icon
meschruhms0





Contest List
Get Started: Download
  Windows    OSX    Linux  
Windows
(Vista/7/8)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons