puzzle picture
404: De-novo Freestyle 4
Status: Closed


Name: 404: De-novo Freestyle 4
Status: Closed
Created: 03/09/2011
Points: 100
Expired: 03/16/2011 - 23:00
Difficulty: Advanced
Description: This currently unsolved protein does not have any templates that we can use, so we are giving it to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well.
Categories: Overall, Prediction

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beta_helix's picture
User offline. Last seen 4 hours 13 min ago. Offline
Joined: 05/09/2008
Groups: None
Please try to use these secondary structure predictions:

As requested in the feedback, http://fold.it/portal/node/989298, these secondary structure predictions have been pre-loaded into this freestyle puzzle.

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Isoleucine at residue 29 is highly predicted to be part of a helix. However, the Leucine at residue 97 is predicted to have an equal probability of being anything.

Joined: 03/09/2011
Groups: None

What would this protein do, ideally, if a solution were found?

beta_helix's picture
User offline. Last seen 4 hours 13 min ago. Offline
Joined: 05/09/2008
Groups: None
I believe it is an RNA-binding protein
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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