Something seems to be wrong with the first segment of the puzzle.
Not the <15 not the <150 version.

If you select all mutable segments (excluding ligand and non-mutable segment 1) and try to replace them, by:

selet_index_range(2,116)
replace_aa("g")

the game quits, as if you have closed the window.

Last error lines are:

Autosaved autosave-119022-988350.ir_solution.
core.conformation.Residue: [ ERROR ] missing atom 1 ( N ) in GLY is its own stub

ERROR: Endless loop in fill_missing_atoms()
ERROR:: Exit from: ..\..\src\core\conformation\Residue.cc line: 580