Yes, or red/green.

There are several stereoscopic solutions available that should work out-of-the-box for Foldit without software modification.

1. (Most likely to succeed) Nvidia 3D Vision. LCD shutter glasses.

2. A pair of ASUS LCD shutter glasses.

3. A pair of ELSA Revelator glasses, combined with a riva TNT2 graphics card (oldskool AGP connection). As long as Foldit uses Z-buffering it should work. I have used this in the past and it is very convincing.

I have an eye condition which allows me to see Foldit models in semi-stereoscopy (depth in the flat plane). It does aid in the understanding of 3-d layout, but does not help much in moving things around as the UI is still combersome in that respect. A gesture interface 'pick it and move it around' would be more beneficial, like VPL powergloves or Oblong's G-Speak. (http://oblong.com/). Think: KiNect or Wii.

Tried use iZ3D but it not working in foldit (it uses directx not opengl).

You're forgetting us colorblind folks, again. For it to be useful to me, it would have to be done with two slightly different images side by side, like the old stereograms were done.

I have started the initiative to explore the possibilities of connecting the WiiMote and Nunchuck to a PC in combination with Foldit. I will post updates when available. I do not have a Mac, so cannot test that.