puzzle picture
353: CASP9 Refinement Puzzle 10
Status: Closed


151compotatoj 51 1399 Anthropic Dreams8,8441
152xiando 51 1399 Oma Gawd8,8381
153Kamel5547 51 1399  8,8271
154martinf 51 1399  8,7971
155chrisalexlucero 51 1399  8,7951
156pjb81 51 1399  8,7951
157ledrekdt 51 1399  8,7941
158Paraprosdokian 51 1399  8,7931
159Monty Carlo 51 1399  8,7691
160grastgirl 51 1399  8,7651
161thenoob 51 1399  8,7631
162Melton 51 1399  8,7541
163Jarretinha 51 1399  8,7441
164rafalcieslak 51 1399  8,7381
165Seneca 51 1399 Crunching Family8,7351
166shockinggrey541 51 1399  8,7251
167brtzsnr 51 1399  8,7191
168Ollathir 51 1399  8,7091
169Zharra_69 51 1399  8,7031
170LLawliet 51 1399  8,7031
171282894jd 51 1399  8,6981
172NR22 51 1399  8,6901
173heretik 51 1399  8,6901
174ralthain 51 1399  8,6891
175poiuytrewq 51 1399  8,6801

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beta_helix's picture
User offline. Last seen 1 week 4 days ago. Offline
Joined: 05/09/2008
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This one will not be easy!

So this last CASP9 refinement target will not be easy.
The CASP9 organizers have told us that the best submitted model for this target had a GDT_TS of 56 which is quite low (a score of 100 is a perfect match to the native).

This means that you will need to heavily refine the starting model, especially in the regions that they mention (residues 10, 20 and 50) shown in note mode.

To make this even harder, the starting model they have selected is the Rosetta model submitted by our human group in the Baker Lab, which is trapped in a local minimum and highly minimized (essentially wiggled to death) so it will be very difficult to improve the score unless you get very close to the native state.

This is why we had to bring back the conditions for this one. It is in your best interest to focus on the regions with conditions immediately from the start (as opposed to wiggling/shaking the starting model) so that your starting very best score will be as low as possible.
This way, hopefully once you've made enough improvements on the 3 regions with conditions you will be able to beat the score of the starting puzzle.

Because we realize how much of a challenge this is, we will also post another version of this puzzle without conditions that will hopefully be useful.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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