puzzle picture
353: CASP9 Refinement Puzzle 10
Status: Closed


126MooMooMan 51 1399  8,9941
127shriah 51 1399  8,9911
128ultimatefolder 51 1399  8,9911
129kanagylab 51 1399  8,9901
130WombatFromHell 51 1399 Shacknews8,9801
131Canada_David 51 1399 Team Commonwealth8,9611
132xenomessiah 51 1399  8,9591
133Lockhart 51 1399  8,9581
134ORBAT 51 1399  8,9521
135felipec 51 1399  8,9471
136jp824 51 1399  8,9361
137thegnat777 51 1399  8,9261
138wozzarelli 51 1399  8,9121
139Lokoman 51 1399  8,9031
140jccarlin 51 1399 8,8991
141daijumao 51 1399  8,8991
142Merf 51 109  8,8871
143Aazhyd 51 1399  8,8871
144domokun 51 1399  8,8841
145hamatoyoshi 51 1399  8,8681
146Halff 51 1399  8,8601
147JPP 51 1399 L'Alliance Francophone8,8581
148xone 51 1399  8,8491
149tjohnson 51 1399 Mmm Helix Fries.8,8491
150translorentz 51 1399  8,8481

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beta_helix's picture
User offline. Last seen 1 week 4 days ago. Offline
Joined: 05/09/2008
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This one will not be easy!

So this last CASP9 refinement target will not be easy.
The CASP9 organizers have told us that the best submitted model for this target had a GDT_TS of 56 which is quite low (a score of 100 is a perfect match to the native).

This means that you will need to heavily refine the starting model, especially in the regions that they mention (residues 10, 20 and 50) shown in note mode.

To make this even harder, the starting model they have selected is the Rosetta model submitted by our human group in the Baker Lab, which is trapped in a local minimum and highly minimized (essentially wiggled to death) so it will be very difficult to improve the score unless you get very close to the native state.

This is why we had to bring back the conditions for this one. It is in your best interest to focus on the regions with conditions immediately from the start (as opposed to wiggling/shaking the starting model) so that your starting very best score will be as low as possible.
This way, hopefully once you've made enough improvements on the 3 regions with conditions you will be able to beat the score of the starting puzzle.

Because we realize how much of a challenge this is, we will also post another version of this puzzle without conditions that will hopefully be useful.

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