Experimental tests of anti-influenza designs

We have now analyzed your redesigns of the last anti-influenza puzzle
and found the solution by user Vakobo to be extremely promising! Vakobo reformed a
loop into a helix introducing new hydrophobic interactions with
hemagglutinin which weren't there in the original design. We'll experimentally
test Vakobo's solution in the lab over the next few weeks and hopefully it will turn
out to be a binder. We'll keep you posted! Thanks to Vakobo and all of the other
participants in this puzzle. We hope that you'll participate in the new puzzles that
we've posted. We're excited to test your ideas!

( Posted by  sarelf 70 1550  |  Thu, 04/22/2010 - 00:44  |  1 comment )
Joined: 12/06/2008
Groups: Contenders
Good show!

Good show, Vakobo! Let's hope your design bears fruit, and you get your name in a publication.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons