puzzle picture

263: Alignment Freestyle

Status: Closed

Soloists

Rank	Player	Group	Score	Points
1	Bletchley Park 9 8	Contenders	9,504	100
2	Mark- 46 1399	Contenders	9,504	95
3	keypad5 46 1399	Richard Dawkins Foundation	9,503	89
4	Madde 46 1399	Void Crushers	9,497	84
5	TheGUmmer 46 169	Void Crushers	9,484	79
6	steveB 46 1399	Void Crushers	9,481	74
7	HillObserver 46 1399	Void Crushers	9,453	70
8	mimi 46 1399	Contenders	9,452	65
9	Nicky666 46 1399		9,447	61
10	calhoun 46 1399	Crunching Family	9,427	58
11	Brick 46 1399		9,412	54
12	vertex 46 1399	Richard Dawkins Foundation	9,379	51
13	lilovip 46 1399		9,368	47
14	vakobo 46 741	Russian team	9,352	44
15	sirenbrian 46 1399		9,340	41
16	Mr_Jolty 46 1399	Natural Abilities	9,337	39
17	spvincent 31 13		9,335	36
18	jobo0502 46 22	L'Alliance Francophone	9,325	34
19	russ 46 1399		9,319	32
20	mat747 46 1399	Void Crushers	9,316	29
21	infjamc 29 19		9,308	27
22	weitzen 46 1399		9,307	26
23	Dolichwier 46 1399		9,304	24
24	caglar 46 1399		9,266	22
25	seppomat 46 1399		9,261	21

Need this puzzle? Log in to download.

Comments

Thu, 02/25/2010 - 02:37

#1

lilovip 46 1399

lilovip's picture

Offline

Joined: 11/11/2009

Groups: None

Alignment variants

Let's look what alignment variants we actually have at this puzzle. It's easy to see there is only one place where we can play with alignment sequence: at the place of 2-aa size space. Changing at any other places will cause huge alignment points reduce. Known protein has the following aa sequence at that place:
SDSQND
And our protein has at start:
LSPxxE
So, now we can place two spaces within this six positions as we wish: they all will give 121 alignment points. I've tryed almost all of the variants. There is table of points for some of them (after alignment and the same sequence of recipes, which I found good):
xLSxPE 9026
LSPExx 9073
LSxxPE 9105
LxxSPE 9133
xxLSPE 9200
LxSPxE 9260
The last one is the best I think, so I've played with it some more time, and now I have 9293 points. If you can to proof any other alignment variant is better, post it here, please.
Happy folding.


	User login Username: * Password: * Create new account Request new password

Download links:


Windows (7/8/10)	OSX (10.12 or later)	Linux (64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.


	Social Media


	Search Only search fold.it


	Click here to read Foldit's statement on the Black Lives Matter movement.


	Other Games: Mozak

Recommend Foldit


	Topics
	Forums temporarily locked due to spam Happy few Gold players in History Interview with DeepMind's Demis Hassabis timing for "share with scientists"? extend deadline for AlphaFold submissions?


	Top New Users Benjamin_F fracata Zhang Ruichong marto808 SonaKona

Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons