puzzle picture
263: Alignment Freestyle
Status: Closed

Groups

RankGroupScorePoints
1Void Crushers9,507100
2Contenders9,50668
3Richard Dawkins Foundation9,50344
4Another Hour Another Point9,44728
5Crunching Family9,42718
6Free-DC9,41211
7Russian team9,3936
8Natural Abilities9,3374
9L'Alliance Francophone9,3252
109,3081
11Team China9,2141
12SETI.Germany9,1601
13ExPitneyFolders8,9701
14sfb5798,9651
15Folders for Awesome8,5901
16Rechenkraft.net8,5271
17Team South Africa8,5131
188,4751
19Ukraine8,1891


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Comments

lilovip's picture
User offline. Last seen 1 year 50 weeks ago. Offline
Joined: 11/11/2009
Groups: None
Alignment variants

Let's look what alignment variants we actually have at this puzzle. It's easy to see there is only one place where we can play with alignment sequence: at the place of 2-aa size space. Changing at any other places will cause huge alignment points reduce. Known protein has the following aa sequence at that place:
SDSQND
And our protein has at start:
LSPxxE
So, now we can place two spaces within this six positions as we wish: they all will give 121 alignment points. I've tryed almost all of the variants. There is table of points for some of them (after alignment and the same sequence of recipes, which I found good):
xLSxPE 9026
LSPExx 9073
LSxxPE 9105
LxxSPE 9133
xxLSPE 9200
LxSPxE 9260
The last one is the best I think, so I've played with it some more time, and now I have 9293 points. If you can to proof any other alignment variant is better, post it here, please.
Happy folding.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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