Side chain reference scores in 254
| Case number: | 699969-987294 |
| Topic: | General |
| Opened by: | infjamc |
| Status: | Closed |
| Assigned: | admin |
| Priority: | 5-Low |
| Type: | Question |
| Opened on: | Friday, January 29, 2010 - 00:40 |
| Last modified: | Tuesday, August 23, 2011 - 20:21 |
In the latest protein-DNA binding puzzle, mutating the alanines to cysteine does not incur the regular -17 penalty in the reference score, while the usage of large aromatics (Phe/Tyr/Trp and even His) now incur a 13/11/27/11-point penalty. Is this intentional to discourage their overuse relative to proteins found naturally?
![](http://128.95.1.228:8000/tracking_pixel.gif?events=scAdd&f=1111&wdata={"x":12, "y":11}){kind=tracking}
Wow, how do you know all of this?
Please tell me.
I also want a score spreadsheet.