Side chain reference scores in 254
|Opened on:||Friday, January 29, 2010 - 00:40|
|Last modified:||Tuesday, August 23, 2011 - 20:21|
In the latest protein-DNA binding puzzle, mutating the alanines to cysteine does not incur the regular -17 penalty in the reference score, while the usage of large aromatics (Phe/Tyr/Trp and even His) now incur a 13/11/27/11-point penalty. Is this intentional to discourage their overuse relative to proteins found naturally?