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219: Hold On To Me
Status: Closed
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Summary
| Name: | 219: Hold On To Me |
|---|---|
| Status: | Closed |
| Created: | 10/31/2009 |
| Points: | 100 |
| Difficulty: | Advanced |
| Description: | Ever get a hankering for redesigning a glycerolphosphate synthase into a biotin binding protein? I sometimes do, which is why I've made this nice puzzle for you. This puzzle also has a single constraint meant to encourage the biotin tail to face outwards into the solvent. (Imagine a linker is attached at the tail end). You're allowed to move the backbone a little bit in this one too. SCORING: The ligand score is the primary contributor to the puzzle score. However, the other designable residues also contribute to a much less extend. Finally, the designable residues scores are also weighted based on their occurance in the multiple sequence alignment of the original scaffold. |
