Feature request: ability to fold proteins as several smaller pieces
|Opened on:||Friday, October 23, 2009 - 01:25|
|Last modified:||Tuesday, February 7, 2012 - 23:10|
In certain puzzles, cutpoints are added to specific locations as constraints, to ensure that two neighboring residues have the proper distance between them. Now, given that freestyle folding puzzles start with an extended configuration, it would be really helpful if we could add our own cutpoints so that smaller segments of the protein could be manipulated separately.
==> Why is this necessary? Currently, there is no way to change the backbone configuration without affecting the rest of the protein unless one freezes off certain segments. But if segments are frozen, the endpoints would be fixed, and thus certain manipulations would be impossible (e.g. straightening a helix). The solution? Cut the protein into pieces, fold the smaller pieces separately, and then glue them back together. Of course, the cutpoints need to suffer from a backbone score penalty modified by distance, and another behavior tab for backbone score would be needed so that the pieces would not come back together in undesired ways until the folder wants to glue them back.