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Joined: 11/12/2007

Hey. Please post you comments on the experimental new folding modes we've created, the "Rubber Band," "Pin," "Pivot," and "Harden" tools. They're located in the "Test" tab on the bottom. Are these tools useful? Should they be kept in the game? Might they be combined somehow? This would also be a great place for you to give us feedback on the existing tools, especially "Drag" and "Backbone."

-- The Fold It! Team

Joined: 01/21/2008
Groups: None
Pivot Tool and Question

I'm fond of the pivot tool. Question: If my structure turns into a complete disaster and I want to start over, can I reset the backbone to its "original" state (i.e. how it is when the puzzle starts)? When I click on the "Backbone Tool" there's a button in the top left that says "Reset Structures" which seems to me should do this, but when I click on it nothing happens...

zoran's picture
User offline. Last seen 2 weeks 6 days ago. Offline
Joined: 11/10/2007
Groups: Window Group
You should be able to get

You should be able to get back to any place in the past by clicking to a specific place on the undo graph.

reset structures is resetting secondary structures (the durations of strands, helices, loops), in case you've changed them.  if you haven't it will appear to not do anything.

Joined: 11/12/2007
Restarting a puzzle.

You can completely restart a puzzle by clicking on File->Switch Puzzle (or hit control-p) and then select the current puzzle again. This will return you to the original configuration (and delete all undo information). To prevent loosing previous progress, you can always save your current state with File->Save As (or control-s).

Joined: 12/07/2007
Groups: Street Smarts
Limits of "undo"

The "undo" only lets you go back about 20 steps. So reloading the original puzzle is the answer. And you might want to save locally your version prior to beginning again, just in case, in the end, it doesn't look so bad after all.

Joined: 12/07/2007
Groups: Street Smarts
Rubber bands

They actually seem to do harm to a model that's already tight. It is as if the backbone is not flexing while they pull. So I would almost want to establish the bands and then be able to do a drag where things will still flex and get some rotation.

Joined: 11/12/2007
bands in the structures

this is a very interesting idea... I think we're starting to have a better picture of how all the tools should come together.

Joined: 06/08/2008
Groups: None
Tools to make Common Protein Shapes ?!

Hi everyone.

While I am away from my desk, I was thinking about the shapes more proteins like to comform to.

Letters/numbers that the protein backbone like to form into are similar to:

M,U,C,S,G,V,L,M,I,N,j,W,e,y + 1,3,5,6,7,8,9,0

Although some letters would include a helix type twist at times, like an E,P,G,Q,R or 3,8 etc...

There would be both rounded and square combinations to those common. ( please add your own too! )

There would be combinations of "common" amino acids that like to hang out with one another too, it sets or combinations that are popular to many species/lifeforms. thus perhaps a possibility to scan each protein for both letters and aminoacid pairs/combos to use as a guide to folding/designing new proteins.

of course some of the shapes are 3D or not exactly the same, but more commonly are.

the range of segments needed to form a shape are from 1 segment arched around, or from 2, 3, 4, 5, 6 etc... to complete the protein.

Often the protein is seperated into 2 hemispheres, 4 or divided via helix's along with sheets to match, or one of the letters/numbers listed above. ( perhaps different alphabets hold better combinations from different languages/character sets)

A tool to assist with a particular shape, along with horizontal or vertical positioning may be useful in the near future. (or those that are known to hold some relevance to certian motor function or energy /bond transferance.

Kia Kaha,

Aotearoa

Supported by: UW Center for Game Science, UW Department of Computer Science and Engineering, UW Baker Lab, DARPA, NSF, HHMI, Microsoft, and Adobe