The response after a mouse click or keystroke is inconsistent. For example, the (top left) objectives dropdown menu is intermittently slow or even non-responsive. Sometimes it is slow to drop down and then slow to collapse (many seconds). Sometimes it drops down immediately and sometimes it fails to drop down at all and sometimes it fails to collapse, leaving the user with the left side of the screen obscured by the dropdown menu. This behavior also occurs with the small molecule design window. Windows 10, only running one client, various puzzles.