puzzle picture
Design of the Month: December 2021
Status: Closed

Summary

Name: Design of the Month: December 2021
Status: Closed
Created: 11/30/2021
Points: 0
Expired: 12/31/2021 - 23:00
Difficulty: Intermediate
Description: This sandbox puzzle features a small molecule design by an anonymous player in Puzzle 2062: VHL Ligand Design: Round 2. The central structure of this molecule has been modified with an aromatic ring system, which backs up a key hydroxyl that makes two critical H-bonds to the target protein. Keep an eye on the cLogP and TPSA Objectives to strike a balance between the hydrophobic and polar atoms in your small molecule designs! For more, check out Foldit Lab Report #27 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

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Categories:

Top Groups

RankGroupScorePoints
1Gargleblasters20,0900
2Go Science19,9970
3Czech National Team19,8610
4L'Alliance Francophone19,8410
5AlphaFold19,7460

Top Evolvers

RankPlayerGroupScorePoints
1Beany 18 49 Gargleblasters20,0900

Top Soloists

RankPlayerGroupScorePoints
1HuubR 26 13 Gargleblasters20,0880
2Aubade01 60 32  20,0840
3NinjaGreg 22 10 Go Science19,9970
4NeLikomSheet 60 35  19,9900
5zackallen 60 85  19,9520


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons