puzzle picture
2061: Symmetric Trimer Design with AlphaFold Predictions
Status: Closed

Groups

RankGroupScorePoints
1Go Science20,545100
2Gargleblasters20,35968
3Anthropic Dreams20,23944
4Contenders20,22727
5Beta Folders20,14716
6L'Alliance Francophone17,7839
7BOINC@Poland17,4855
8Australia17,0213
9AlphaFold15,4751
10:)14,1451
11Czech National Team13,8991
12Void Crushers12,7041
13Marvin's bunch01
14Foldit Staff01


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Comments

bkoep's picture
User offline. Last seen 2 hours 5 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 3 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

jeff101's picture
User offline. Last seen 6 hours 20 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
How many segments per monomer?

I am curious how many residues there are per monomer in this puzzle.

LociOiling's picture
User offline. Last seen 2 hours 50 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
70 segments

They should really include this info in the puzzle description, but there are a couple of easy ways to get it.

In the selection interface, control + a to select all shows the count in the upper left if the GUI is visible.

Otherwise, recipes that include AddMax, AA Edit, print protein, and others give the count.

jeff101's picture
User offline. Last seen 6 hours 20 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Thanks LociOiling.

I just like to know before I start a puzzle what it entails.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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