Developer Preview Release Soon

Hey everyone,

We're about to push a big update to the developer preview soon with additions and changes to Foldit Small Molecule Design. You can read more about this exciting new mode here. Read below for a full list of the changes:

* A major overhaul and update to the Small Molecule Design tool.
* Two new tutorials demonstrating how to use Small Molecule Design.
* A new "Binding Site" option in the "View Protein" section of the View Options -- this is like Cartoon Ligand, but hides parts of the protein which are far from the ligand.
* Updates to the underlying small molecule handling code.
* Updates to the Ligand Substructure objective.

(Wed, 10/13/2021 - 01:52  |  6 comments)
cas0362's picture
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Difficult to visualize ligand atom types

Combination of overlaid h bond indicators and all orange in edit mode makes this difficult.

rmoretti's picture
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Change view options

Sorry about that - this has to do with your view option settings. Some of the view options which are more tailored for protein folding and protein design don't work too well for ligand design puzzles.

We recommend you adjust your view options to Color: "Score/Hydro+CPK" and View Protein: "Binding Site" (or "Cartoon Ligand"). But feel free to play around with the view settings to come up with settings that you like best. (For those who aren't too familiar with the Selection Interface, you can get to the View Options dialog by clicking the green Foldit button in the lower left corner.)

We're looking into ways of adjusting the puzzle setting such that we can load recommended view options on puzzle load, but for now you'll have to tweak things manually.

cas0362's picture
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Atom types also lost during editing process

Many thanks for the suggestion. It seems that during each edit the atoms types are also lost so the view settings need to be adjusted each time. This makes the editing process more difficult.

jflat06's picture
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Groups: Window Group
Hotfix 10/13

Bug Fixes:
* Fix crashes on re-loading small molecule design puzzles.
* Fixed a crash from a missing small molecule design file.
* Fixed some word choice in the small molecule design tutorials.

cas0362's picture
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Possible to play ligand design tutorials without others ?

Is it possible to play the ligand design tutorials without first playing the protein folding tutorials? This would be useful in my opinion as a quicker entry into ligand design.

cas0362's picture
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Currently ctrl z and undo panel need multiple clicks

Three clicks to undo one edit if I see it correctly.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons