puzzle picture
Design of the Month: April 2021
Status: Active

Summary

Name: Design of the Month: April 2021
Status: Active
Created: 03/31/2021
Points: 0
Expires: 04/30/2021 - 23:00
Difficulty: Intermediate
Description: This sandbox puzzle features three solutions submitted by LociOiling for our Influenza HA Binder Design Competition. Reset the puzzle to cycle through the three different designs. All of these designed binders look like they have a good chance of folding correctly, and orange hydrophobic residues at the target interface will make for tight binding. Look out for blue polar sidechains on the target that are buried by the binder; if the binder does not make H-bonds with the polar atoms on these sidechains, they will become unstable BUNS and prevent binding! For more, check out Foldit Lab Report #19 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Categories:

Top Groups

RankGroupScorePoints
1L'Alliance Francophone10,598
2Italiani Al Lavoro10,531
3Go Science10,462
4Void Crushers10,460
5Olsztynek10,458

Top Evolvers

RankPlayerGroupScorePoints
1Hollinas 66 1350 Go Science10,175

Top Soloists



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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons