P1939 Linker new CMS bonus uncapped
| Case number: | 671071-2011036 |
| Topic: | Game: Other |
| Opened by: | John McLeod |
| Status: | Open |
| Type: | Bug |
| Opened on: | Thursday, January 7, 2021 - 13:19 |
| Last modified: | Thursday, January 14, 2021 - 01:27 |
20201223-e20c1e0f15-win_x86-devprev
Main group is I believe equivalent
In new Puzzle 1939 Linker, after about 8 hours running Mutate Combo 1.4 for Layers new ContactMolecularSurface Score +3564.47 points (and Secondary Structures at -300 points). This pose has just been Shared with Scientists. Public Recipe here:
https://fold.it/portal/recipe/44581
Player ichwilldiesennamen earlier noted this in the Puzzle 1939 comments here:
https://fold.it/portal/node/2011030#comment-43832
Thank you for documenting this bug.
Please report and document bugs in one place only, here in feedback, not in Discord.
Most of the top scoring solutions for 1939 were heavily saturated with tryptophans. This indicates a scoring bias towards larger AAs, which are not necessarily the best ones.
I had four tryptophans in my five-helix solution for 1939, all located on the outside of my helices (and flagged as exposed) and not interacting with any other sidechains or either of the target proteins. When I substituted more appropriate sidechains (glutamate, lysine, arginine), my score dropped hundreds of points. That didn't happen before the CMS metric was in play, further lending weight to the idea of a faulty scoring mechanism for CMS.
yes, the CMS produce wrong AA's, if you mutate!
I have everything documented in Discord:
https://discordapp.com/channels/676550660694605825/685215543338336347/797027564086099968