Sat, 12/26/2020 - 02:33
#2
BluePrint solutions from earlier 1903b
Formula350 offers fixes for Blueprint moving the locked helix bundle (this time it's segments 1 to 52):
https://fold.it/portal/node/2010556#comment-43141
Sat, 12/26/2020 - 07:25
#3
residue count filter is misquoted above
I checked and the maximum on the residue count filter is 2200 points. Each additional residue costs 55 points, with a maximum added count of 40 bringing the filter bonus down to 0 points.
Sun, 12/27/2020 - 04:01
#4
You're right!
I've amended the Objectives details in the comment above.
Sun, 12/27/2020 - 14:26
#5
while you're at it ...
Buried Unsats only cost -50 each in this puzzle, as it happens. Lucky for me.
Core Existence: Chain A (max +5000)
Ensures that at least 24% of residues are buried in the core of the entire solution.
Core Existence: Chain B (max +5000)
Ensures that at least 24% of residues are buried in the core of the entire solution.
Core Existence: Total (max +5000)
Ensures that at least 30% of residues are buried in the core of the entire solution.
Residue Count (max
+2000+2200)Penalizes added residues at a cost of
5055 pts per residue. Players may add up to 40 residues, for a total of 220.Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds,
-150-50 points per atom (not including symmetric copies).Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, SER, THR in helices.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.