1929: Two-sided Interface Design
|Name:||1929: Two-sided Interface Design|
|Expired:||12/18/2020 - 23:00|
|Description:||Design an interface between two protein chains! This is a followup puzzle to Puzzle 1903b, with a greater allowance of insertable residues and a stricter Core Existence Objective. The starting structure includes two helical hairpins that are frozen in place and separated from one another. We want to build on these hairpins to create a binding interface between the two protein chains. However, the starting position of the hairpins is important, so the locked hairpins are held in place by strong constraints. The only way to make the two chains bind will be to fold up a brand new interface between them.
As you build on the two hairpins, it will be important to make a strong core with each chain, so that the chains fold up correctly. It will also be important to have a strong core at the interface where the two chains come together, so that they bind each other tightly. Keep an eye on the Core Existence Objective, which tracks all of these core residues together. Players may add up to 40 additional residues at a cost of 55 points per residue. See the puzzle comments for Objective details.
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