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1921: Designable Linker: Coronavirus Spike Binder
Status: Closed

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neilpg628's picture
User offline. Last seen 1 day 14 hours ago. Offline
Joined: 08/01/2019
Groups: Foldit Staff
Objectives

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 240, at a cost of 55 points per residue. Players may use up to 250 residues in total.

Core Existence (max +2400)
Ensures that at least 35 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Prohibits CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Joined: 12/06/2008
Groups: Contenders
Constant crashing?

Anyone else experiencing constant crashing of the game while playing this puzzle? There is no one action I do that causes the crash.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons