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1921: Designable Linker: Coronavirus Spike Binder
Status: Closed
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Soloists
1 | ZeroLeak7 18 4 | Go Science | 25,157 | 100 | 2 | Enzyme 52 3 | Gargleblasters | 25,118 | 98 | 3 | ichwilldiesennamen 4 1 | Go Science | 24,970 | 95 | 4 | grogar7 53 2 | Anthropic Dreams | 24,946 | 92 | 5 | spvincent 36 15 | Contenders | 24,858 | 89 | 6 | mirp 1 8 | Go Science | 24,640 | 87 | 7 | johnmitch 87 11 | | 24,505 | 84 | 8 | akaaka 87 21 | | 24,496 | 82 | 9 | Mike Lewis 15 24 | Gargleblasters | 24,391 | 79 | 10 | g_b 87 14 | | 24,372 | 77 | 11 | martinzblavy 59 72 | Contenders | 24,351 | 75 | 12 | Galaxie 5 9 | Anthropic Dreams | 24,273 | 72 | 13 | dcrwheeler 87 6 | | 24,272 | 70 | 14 | LociOiling 9 5 | Beta Folders | 24,272 | 68 | 15 | jeff101 44 124 | Go Science | 24,264 | 66 | 16 | fiendish_ghoul 87 12 | | 24,233 | 64 | 17 | Bruno Kestemont 2 7 | Go Science | 24,205 | 62 | 18 | Joanna_H 48 77 | Gargleblasters | 24,179 | 60 | 19 | Ashrai 32 62 | Gargleblasters | 24,178 | 58 | 20 | Skippysk8s 25 28 | Gargleblasters | 24,169 | 56 | 21 | phi16 13 17 | Anthropic Dreams | 24,153 | 54 | 22 | NeLikomSheet 87 23 | | 24,130 | 53 | 23 | Blipperman 24 36 | Gargleblasters | 24,066 | 51 | 24 | John McLeod 62 27 | Anthropic Dreams | 24,047 | 49 | 25 | BootsMcGraw 16 10 | Contenders | 24,037 | 48 | Need this puzzle? Log in to download.
Comments
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Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 240, at a cost of 55 points per residue. Players may use up to 250 residues in total.
Core Existence (max +2400)
Ensures that at least 35 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
SS Design (max +500)
Prohibits CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.