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1909: Symmetric Tetramer Design: H-bond Networks
Status: Closed
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Evolvers
1 | mirp 46 1458 | Go Science | 21,584 | 100 | 2 | Bruno Kestemont 3 2 | Go Science | 21,574 | 96 | 3 | Dhalion 46 1458 | Go Science | 21,534 | 92 | 4 | ichwilldiesennamen 22 10 | Go Science | 21,516 | 88 | 5 | Czim 46 1458 | Go Science | 21,503 | 84 | 6 | toshiue 46 863 | Go Science | 21,468 | 81 | 7 | OWM3 46 1458 | Gargleblasters | 21,398 | 77 | 8 | Mike Lewis 46 1458 | Gargleblasters | 21,353 | 74 | 9 | Skippysk8s 34 28 | Gargleblasters | 21,346 | 70 | 10 | cjddig 46 114 | Gargleblasters | 21,321 | 67 | 11 | Ashrai 46 1458 | Gargleblasters | 21,319 | 64 | 12 | silent gene 24 66 | Go Science | 21,300 | 61 | 13 | Bletchley Park 8 8 | Contenders | 21,270 | 58 | 14 | spvincent 29 12 | Contenders | 21,224 | 56 | 15 | kyoota 11 41 | Go Science | 21,110 | 53 | 16 | fisherlr777 46 1458 | Go Science | 21,081 | 51 | 17 | BootsMcGraw 10 7 | Contenders | 21,040 | 48 | 18 | CharlieFortsCon... 46 1458 | Contenders | 20,989 | 46 | 19 | GriffJ572 46 1458 | Go Science | 20,436 | 44 | 20 | Galaxie 1 3 | Anthropic Dreams | 20,058 | 41 | 21 | phi16 9 29 | Anthropic Dreams | 20,044 | 39 | 22 | John McLeod 46 1458 | Anthropic Dreams | 19,835 | 37 | 23 | alcor29 5 9 | Anthropic Dreams | 19,780 | 35 | 24 | LociOiling 2 1 | Beta Folders | 19,775 | 34 | 25 | robgee 7 6 | Anthropic Dreams | 19,720 | 32 | Need this puzzle? Log in to download.
Comments
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Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -200 points per atom (not including symmetric copies).
Core Existence: Monomer (max +2200)
Ensures that at least 22 residues are buried in the core of the monomer unit.
Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.
H-bond Network (max +1800)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).
Interaction Energy (max +500)Monitors that all large PHE, TYR, and TRP residues are scoring well.
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.