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1902: Aflatoxin Challenge: Round 18 Loop Prediction
Status: Closed


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Joined: 12/06/2008
Groups: Contenders
Where are the loops?

You say there are two binding loops, but only one is obvious to me. Can you please identify the positions of the two loops?

malphis's picture
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I think the second is 105-114. When I tug on it the score changes. It is also colored as opposed to the greyed locked area, but color blindness might interfere with seeing it. The other is 35-65.

LociOiling's picture
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Malphis is correct, the moveable parts are:

  • 36-65
  • 105-114

These are the moveable parts, with unlocked backbone. They can't be mutated, however, so they're not "designable".

If you select EnzDes coloring and Cartoon or Cartoon Thin, there should be a contrast between these sections and the locked part.

In color blind mode, the moveable parts show in in a lighter color with these settings. To me, they're a lighter green, while the locked parts are kind of gray-green.

There are also several sections with locked backbone, but moveable sidechains.

The easiest way to see these sections is to use the selection interface, the do a control-a to select all. The moveable backbone parts and the moveable sidechains parts then show up in blue, again a good contrast with the totally locked part.

The recipe print protein also identifies these sections as segment ranges. The latest version uses Lua table format:

unlocked_sidechain = {
    { 4, 14, },
    { 16, 16, },
    { 24, 25, },
    { 32, 32, },
    { 35, 71, },
    { 81, 81, },
    { 83, 83, },
    { 85, 98, },
    { 101, 103, },
    { 105, 114, },
    { 130, 133, },
    { 143, 143, },
    { 149, 149, },
    { 155, 155, },
    { 158, 158, },
    { 160, 161, },
    { 168, 168, },

The table includes the moveable backbone parts.

When you show all sidechains, these unlocked sidechains should show as more lighter or more colorful, while backbone will be darker where it's locked.

(Edit: corrected first moveable segment, it's 36, not 35, and also this is not a design puzzle, so it's "moveable", not "designable".)

Joined: 12/06/2008
Groups: Contenders
Thank you.

Thanks to Loci and malphis for the clarification.

Grey, green... they look the same to me. I'll just have to remember the numbers.

Joined: 09/29/2016
Groups: Gargleblasters
There's another way....

Press "F" to Freeze EVERYTHING.
If the backbone and sidechain becomes Frozen, then that is a FULLY "moveable" segment. (Can cut them, change their positions, and their structures)
If only the sidechain becomes Frozen, then all you can do is Shake or Pull on those sidechains because the backbone is Locked.

You can also do one other thing, but it requires Selection Interface: Toggle the "Move Tool" to displace and with nothing selected (press spacebar a couple times to make sure), on the Arrow-Cross you Right-Click and drag the mouse to move (or ctrl+left-click) which will move ALL of the segments we can manipulate.

It's crude, but since they are only connected by un-closable cuts, they're free to be relocated anywhere and will snap-back into place when wiggled.

LociOiling's picture
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corrections and clarifications

It looks like the first moveable section actually starts at 36, not 35. Also, 1902 does not have any mutable segments, so "designable" was not right. It's actually the "moveable" parts we're talking about, unlocked backbone or sidechains. I've made some corrections to the previous post.

Also, while I shared a snapshot from Puzzle 1739, the sequence for that one is not the same as the sequence for 1902. Segments 105-107 are "rds" in 1902, but "kdq" in my best from 1739. Segments 55 and 58 are also different 55 "q" in 1902, was "l" in 1739, while 58 is "a", was "l".

I shared several solutions with scientists on 1739, but so far I haven't found one with same sequence as 1902. I'll keep digging and share anything I find.

Finally, the print protein output shows an number of differences between 1739 and 1902 in which segments have locked backbone and sidechains. Also, the permanent cutpoints appear to be in different spots in the two puzzles, but print protein can't detect this.

LociOiling's picture
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still puzzled by this puzzle

I checked all my leftovers from puzzle 1739, and I still couldn't find an exact match for the amino acid sequence in 1902.

jeff101's picture
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Joined: 04/20/2012
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Maybe your 1739 solution was an intermediate saved automatically

Perhaps the sequence for 1902 actually did come from
one of your 1739 solutions, but it was from one of the
intermediate solutions shared automatically every few
minutes to Foldit instead of one of your Share with
Self, Share with Group, or Share with Scientists

jeff101's picture
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Joined: 04/20/2012
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Perhaps 1902 was a design by Phyx

says 2 LociOiling and 1 Phyx design
from Puzzle 1739 did well. Maybe
1902 is really a Phyx design from

bkoep's picture
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Possible intermediate

I don't know exactly how the Siegel Lab selected solutions, but they were looking at all of the solutions we collected from Puzzle 1739 (including intermediate solutions that are automatically uploaded during gameplay). This may not be a solution you saved in your client. Though I've verified that this solution was indeed created by LociOiling.

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