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1901: Coronavirus Anti-inflammatory Design: Round 14
Status: Closed
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Soloists
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| 1 | Joanna_H 35 16 | Gargleblasters | 12,233 | 100 | | 2 | Bruno Kestemont 2 6 | Go Science | 12,230 | 97 | | 3 | ichwilldiesennamen 5 4 | Go Science | 12,181 | 94 | | 4 | malphis 98 11 | | 12,176 | 91 | | 5 | grogar7 80 2 | Anthropic Dreams | 12,172 | 89 | | 6 | mirp 1 3 | Go Science | 12,118 | 86 | | 7 | jawz101 98 105 | | 12,109 | 83 | | 8 | Galaxie 3 7 | Anthropic Dreams | 12,077 | 78 | | 9 | NinjaGreg 39 15 | Go Science | 12,024 | 75 | | 10 | BootsMcGraw 25 10 | Contenders | 11,999 | 73 | | 11 | OWM3 16 17 | Gargleblasters | 11,997 | 71 | | 12 | Mike Lewis 9 13 | Gargleblasters | 11,994 | 68 | | 13 | dcrwheeler 98 5 | | 11,993 | 66 | | 14 | LociOiling 7 1 | Beta Folders | 11,982 | 64 | | 15 | spvincent 37 24 | Contenders | 11,981 | 62 | | 16 | Vinara 98 48 | | 11,978 | 60 | | 17 | robgee 11 20 | Anthropic Dreams | 11,950 | 58 | | 18 | John McLeod 50 31 | Anthropic Dreams | 11,945 | 56 | | 19 | ZeroLeak7 43 9 | Go Science | 11,934 | 54 | | 20 | ucad 98 29 | | 11,929 | 52 | | 21 | sgeldhof 98 35 | | 11,921 | 50 | | 22 | justjustin 81 28 | Anthropic Dreams | 11,911 | 48 | | 23 | Mike Cassidy 91 36 | Void Crushers | 11,889 | 47 | | 24 | Philzord 76 57 | Go Science | 11,881 | 45 | | 25 | Skippysk8s 18 25 | Gargleblasters | 11,875 | 43 | Need this puzzle? Log in to download.
Comments
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DDG Score (max +0)
The predicted binding energy of your design. The target DDG is -40.0 or less.
SASA Score (max +0)
The solvent-accessible surface area that is lost upon binding. The target SASA is 1500 or more.
Shape Complementarity (max +0)
Measures how well your binder fits the contours of the target surface. The target Shape Complementarity is 0.60 or more.
Buried Unsats (max +500)
Penalizes 60 points for each polar atom that cannot make any H-bonds. Note that the frozen target includes 3 buried unsats that may be impossible to satisfy.
Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 151, at a cost of 55 points per residue. Players may use up to 156 residues in total.
Core Existence (max +1000)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.