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Beginner Puzzle (<150): Coronavirus
Status: Active

Summary

Name: Beginner Puzzle (<150): Coronavirus
Status: Active
Created: 03/03/2020
Points: 100
Expires: 12/17/2020 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Categories: Beginner

Top Groups

RankGroupScorePoints
1Gargleblasters13,742
2Go Science13,528
3Void Crushers13,210
4Russian team13,113
5practice13,097

Top Soloists

RankPlayerGroupScorePoints
1johngran 102 314  13,904
2OWM3 14 13 Gargleblasters13,742
3Dudit 23 69 Go Science13,528
4Kiwegapa 102 505  13,393
5vmurphy1 102 2482  13,326


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons