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1900: Symmetric Trimer Design: H-bond Networks
Status: Closed

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bkoep's picture
User offline. Last seen 11 hours 5 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 3 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

Enzyme's picture
User offline. Last seen 50 years 50 weeks ago. Offline
Joined: 07/10/2008
Groups: None
2 Networks

After spending the last 2 puzzles trying to determine why I can't reach the max bonus for HBond Network, I think I finally found the issue. Only 1 network can contribute to the HBond Network score bonus.
"2 Networks" solution uploaded for Scientists if you wish to review it.

Joined: 03/28/2020
Groups: Go Science
Strange bonus behavior

Yes, I also found some strange behavior with the HBnet bonus. I had a design in which the HBnet which was actually larger than required for 1800 HBnet bonus. But granted bonus was LOWER than 1800. When I deleted a part of the net I got the full 1800 Bonus for this now smaller net. I don't think that this behavior is desired?!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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