DDG Score (max +0)
The predicted binding energy of your design. The target DDG is -40.0 or less.
SASA Score (max +0)
The solvent-accessible surface area that is lost upon binding. The target SASA is 1500 or more.
Shape Complementarity (max +0)
Measures how well your binder fits the contours of the target surface. The target Shape Complementarity is 0.60 or more.
Buried Unsats (max +320)
Penalizes 60 points for each polar atom that cannot make any hydrogen bonds. Note that the frozen target includes 3 buried unsats that may be impossible for players to satisfy.
Residue Count (max +275)
Penalizes extra residues inserted beyond the 177, at a cost of 55 points per residue. Players may use up to 182 residues in total.
Core Existence (max +2400)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.
Bug in objectives: it keeps losing the score. I have restarted both the app and my computer.
I noticed that some of mine solutions in this puzzle with the highest achieved scores does not guarantee best achieved Matrices DDG, SASA and SC. Is this the case? I have read in the blog pages that the new foldit update will try to handle this. As far I understand the docking or binding of the protein to the target may play an important role in SC and DDG but the overall design has to do more with the SASA and therefore higher SASA may related more to the number of protein segments availiable that can cover the binding site. Is this correct or I am loosing something? On the other hand achieving a high score is more or less the design of a good protein core as starting point.
Correction. Metrics is then correct not Matrices!
You're correct that a high score in this puzzle does not guarantee good DDG, SASA, or SC. Those metrics are separate from your score.
We would like to include these metrics in the Foldit score (so that designs with good DDG, SASA, and SC have higher scores), but they are very slow to compute and that raises some technical challenges we have to resolve. Soon we will release an update so that these metrics can add bonus points to your Foldit score!