Please allow SOME alanines in designed helices.

Case number:671071-2010342
Topic:Game: Other
Opened by:BootsMcGraw
Status:Open
Type:Suggestion
Opened on:Thursday, September 17, 2020 - 00:00
Last modified:Thursday, September 17, 2020 - 00:00

We discussed in some of the puzzle comments that having alanine-rich helices may form a good, tight core, but they are not so good in other ways.

There are times when I am working a design puzzle where an alanine seems to be exactly what I need for what I'm trying to attempt. Do I really need to take a fifty point penalty for adding an alanine to my design, when it is the most common amino acid in helices?

I propose keeping a penalty function for alanines in a helix, but only if the helices contain over a certain percentage (5%? 10%) of alanines. Who's with me on this? Hit the up arrow button, below.

(Thu, 09/17/2020 - 00:00  |  0 comments)


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