I'm embarrassed to ask these brainfarts but here they are:
Have there been any challenges to test MRSA treatments?
Are loops less significant than helices and sheets? Would a design based solely on loops do anything in real world?
If you have 2 sheets and you bond them, would it be better if they bond flat, idealize first, or idealize SS, or idealize + idealize SS and then bond those idealized sheets together?
I've wondered if the way scoring works is based on the number of manipulations it would take to achieve the end shape. Is that how energy is scored?
Like if I handed you a coat hanger that I had bent up into a certain shape, is the goal to see what the minimum amount of manipulations it takes to match that shape identically?
I wonder if the goal is simple, repeatable design to achieve the best outcome.
To that end, is the goal to to find a design that is easily reproducible since a drug would have to be mass produced?
One of my first feelings when playing the game was that quote attributed to Michalangelo.
Something like “The sculpture is already complete within the marble block, before I start my work. It is already there, I just have to chisel away the superfluous material.”
What I wondered: is there an approach whereby a perfect shape is known but it's a matter of making that shape with the lowest energy.
That is, could an approach be to reverse engineer what the manipulations would be to make a known, desired shape?
Does protein folding have any relation to origami or knot tying? Maybe 20 years ago I had read that the mathematics of origami was a newer interest in math. Would anything from either of these things translate much to protein folding?
There is probably better info than a couple of wikpedia pages on these 2 math things. I just wanted to find something that talked about the ideas.