puzzle picture
1874: Coronavirus Binder Design: Round 15
Status: Closed

Groups

RankGroupScorePoints
1Gargleblasters14,917100
2Go Science14,81877
3Anthropic Dreams14,78958
4Contenders14,63843
5Beta Folders14,57131
6Void Crushers14,30522
7L'Alliance Francophone14,26315
8Marvin's bunch14,05611
9BOINC@Poland13,5907
10Russian team13,5575
11Hold My Beer13,3773
12Team Poland11,9642
13Boilermakers11,7041
14SETI.Germany11,6461
15Team Canada10,9681
16Team China10,7541
17Hun-Magyar Csapat01
18FoldIt@Netherlands01
19Foldit Staff01
20Window Group01


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bkoep's picture
User offline. Last seen 10 hours 33 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +20)
Penalizes 60 points for each polar atom that cannot make any hydrogen bonds. Note that the frozen target includes 8 buried unsats that may be impossible for players to satisfy.

Residue Count (max +275)
Penalizes extra residues inserted beyond the 177, at a cost of 55 points per residue. Players may use up to 182 residues in total.

Core Existence (max +2400)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

bkoep's picture
User offline. Last seen 10 hours 33 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Devprev puzzle

Devprev users can try loading your solutions into the new devprev puzzle to check the DDG, SASA, and Shape Complementarity metrics of your binder.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons