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Here are all the Foldit newsletters that have been sent out, with the most recent one at the bottom.

If you have questions on any of these newsletters, please feel free to contact mail.fold.it@gmail.com or ask them in Discord

Additionally, if you would like to sign up for our mailing list to receive these newsletters, please click here!

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Newsletter July 3: Initial Reactions

Newsletter July 3: Initial Reactions

Hey folders!

Dev Josh here with your weekly Foldit update.

This week we saw the introduction of the Reaction Design tool. The devs are working hard on polishing it up and making it more usable! As always, thanks for your feedback and bug reports. You can submit more feedback here.

Top Results from Puzzle 1856: Coronavirus Round 12

In this puzzle, I accidentally evo'ed on a broken developer build and got the top score. Whoops, sorry about that!
Here are some of the solutions at the top of the leaderboards. [A note from our scientists: the top of the leaderboards doesn't always mean the most scientifically useful. These highlights are not scientific feedback and are not officially endorsed as scientifically valid designs by the Foldit team.]

Join the mailing list to see what others are folding!

Recipe of the Week

This week's recipe is an oldie but a goodie from drjr. The recipe is called Reset, and it does what it says on the tin: reset to the best score, unfreeze the protein, remove all your bands, and set the CI to 1. A simple recipe, but a handy quality of life tool for when you just need to backtrack a little.

Player of the Week

Quick shoutout to argyrw for always being a friendly voice in chat! Say hi to her in global or veteran chat.

Today’s Master Folding Tips

Beginner: Are you still using Pull to draft your protein in the early game? Try making cutpoints and moving pieces around with the Move tool, it's so much easier! Don't forget to disable cutpoint bands in the Behavior tab, or they'll all come together again when you wiggle.

Intermediate: It can be really tempting mid-game to just switch to running recipes. But give some time to carefully inspect every acceptor and donor (the red and blue dots) to see what hydrogen bonds you can form, and manually mutate as needed. Not only will this lower your BUNS, but it'll help form a strong hbond network. The scientists love this, and your rank will too!

Expert: If you haven't already, read bkoep's blog on binder design metrics. DDG, SASA, and SC are going to become really important soon since we're looking to add objectives for them. So understanding and practicing these principles now can help you get a headstart on the competition! Use the protein design sandbox to try out some ideas.

Have a tip to share or a recipe to recommend? Reply with your suggestions or make a wiki page for your ideas! Reaction Design doesn't have a page yet, so if you understand this tool, help out your community by writing about it! (Since writing this post, LociOiling has graciously created the page for Reaction Design puzzles.)

Until next time, happy folding!

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Newsletter July 10: Triple-Quad Helices and Borromean Rings

Newsletter July 10: Triple-Quad Helices and Borromean Rings

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1858: Symmetric Trimer Design

Personally, I went with a 4-helix design for this puzzle, and it seems like that's what a lot of the highest scoring solutions did. But there were also a couple of 3-helix designs, and even some sheets!

Puzzle 1860: Refinement R1040

The highest scoring solutions for this puzzle kept two medium-sized sheets lined up and folded the rest into short helices around a core.

Compare this to some of the intermediate solutions. Although these folds are okay, they had some minor problems: some loose helices and poor scoring ends.

What was the trickiest part for you about this puzzle? Let's talk about it in Discord!

Recipe of the Week

This week's recipe has been described by Phyx as "The Best Recipe of 2014": Wisky's Repeating Rebuild All!

Let this late-game recipe run for 3-4 hours and it will do some rebuilding magic on your pose.

Player of the Week

I want to honor LociOiling! for constantly being the #1 contributor to our wiki!. This week he created the pages for Reaction Design Puzzles and Camera Controls! If you've ever read a wiki page that was made in the last few years, chances are Loci wrote it. Give him your thanks in chat next time you use the wiki!

Art of the Week

This week's most beautiful fold comes from Formula350 for his Borromean rings! This would never fold up in real life, but wow, is it pretty!

Today’s Master Folding Tips

Beginner: Don't be afraid to reassign your secondary structures to different sheets and helices! While this might seem like you're "changing the puzzle," you're really just making a suggestion for what shape the protein should take, and this suggestion can help your other tools better serve you. Try a bunch of different secondary structure assignments and use Ideal SS on them afterward, then see how this new arrangement might be easier or harder to fold. Play around with it, Foldit is about experimenting!

Intermediate: If you haven't learned to use Backbone Pins yet, I highly recommend it. This tool, hidden away in the view options, gives you more control over wiggling than CI alone. A locked pin is similar to a ZLB, it will keep your wiggle locked to that spot, while moving everything else more.

Expert: Although it might seem like more hbonds means better binding, hbonds at the interface don't actually add to the strength of the bind, since they aren't much stronger than these atoms simply binding to water. What use are interface hbonds then? Their purpose is eliminating BUNS. The real strength of your binding comes from hydrophobic interactions, shown in the Hiding and Packing subscores, and your hbond network gives the bind its specificity.

Want to recommend a recipe of the week or have your solution featured in the next newsletter? Send us your cookbooks and screenshots, we'd love to see what you're up to!

Until next time, happy folding!

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Newsletter July 17: Bonjour Encore Triple Hélice

Newsletter July 17: Bonjour Encore Triple Hélice

Hey folders!

Dev Josh here with your weekly Foldit update.

3 Solutions from This Week's Puzzle

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1861: Symmetric Trimer Design: Buried Unsats

Triple helix is here to stay, look how clean and neat these bundles are! Great job silent gene and Spvincent

This solution took a less common approach to the triple helix meta. I'll let you decide for yourself whether you think it scored well or not. What do you think of it? Let us know in the Discord!

Puzzle 1862: Coronavirus Round 13

An extra special congratulations goes to clark92 for being top rank for this puzzle! This up-and-coming folder only started folding at the end of February, and already they've taken the leaderboards by storm!

These solutions come from some of our beginner folders! Can you tell what they could do better?

As a reminder, here are some helpful tips from bkoep on designing a good binder!

Want to get your top solution featured in the weekly newsletter? Click the "Share with Scientists" button in the "Open/Share Solution" menu and your solution might get featured! Don't forget to fill out our username sharing form if you'd like your username to be shown with your solutions!

Recipe of the Week

Not sure what recipes are good? Check out this all-in-one recipe: Constructor by Grom!
This mini-cookbook contains 19 different recipes all packed in one. Check it out for some inspiration this week!

Player of the Week

Big thanks to nspc this week for putting out two new French tutorial videos on how to get started with design puzzles and prediction puzzles.

If you're still on the intro puzzles, nspc also has a video on beating Hydrophobic Disaster.

I think I speak for everyone when I say merci beaucoup! Nspc (pc on Discord) is a beginner folder who has been learning fast by being really active in the chat. Say hi next time you see them around!

Art of the Week

Here's some art from 1861: a cool-looking triangle and a crazy ball of... I don't even know what... Thanks for sharing!

Today’s Master Folding Tips

Beginner: Despite how common they are, I really recommend trying a helix bundle like the ones you've seen from the top-scoring solutions! Helices are easier to make than loops or sheets, so practicing on helix bundles is a great way to get a higher rank and practice the basics before trying something tricky and advanced like long loops or a sheet structure.

Intermediate: Are you paying attention to which structures your AA structure preferences. AAs prefer to be in? It's not a hard-and-fast rule, but check out the wiki for AA structure preferences. I find this especially helpful for getting started by mutating my isoleucines away into something more suitable for the structure I'm designing, like asparagines for loops, valines for sheets, and MALEK for helices.

Expert: How many structural motifs can you name? Most of you know pi stacking, some of you even know about beta hairpins. But do you know about ST turns, Greek keys, and Omega loops? What about sequence motifs?

Having these concepts in your toolkit will give you more conceptual legos from natural proteins to think about when designing. There's plenty of research out there on common patterns, and if you're looking for expert tips, then you're ready to dig into real literature. Good luck, and let us know what you find on
Discord

Want to give your group a shoutout in the next newsletter? Reply with a blurb about what your group is and why new players should join, and your group might get featured in the next newsletter!

Until next time! Happy folding!

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Newsletter July 24: A Good Week for Go Science

Newsletter July 24: A Good Week for Go Science

Hey folders!

Dev Josh here with your weekly Foldit update. Congratulations to Go Science! for being the top of all three puzzles this week! Go Science has been an open and active group since 2010. One of the best ways to learn and improve in Foldit is to join a group.

If Go Science isn't your style, try the hopeful and determined Anthropic Dreams, the fun and light Gargleblasters, or the dedicated Contenders

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1863: Refinement R1043

I've heard this puzzle was crashing pretty frequently. Thanks for your patience everyone, the devs are hard at work trying to fix these issues!

Puzzle 1864: Symmetric Trimer Design: Limited Interface

To master this puzzle, you needed to limit how big your binding interface was. Notice how the top scores rotated their helical bundles to limit their attachments!

Puzzle 1865: Coronavirus Anti-inflammatory Design 8

Bkoep said there were 15 unsolvable BUNS, but some of the top solutions got them down to 11! Great job on satisfying those BUNS everyone, keep it up!

Want to know more about why we're designing binders from scratch? Check out this forum thread for details on why we're not just using the ACE2 receptor design.

Recipe of the Week

This week's recipe is new but with great potential:
mwm64's UnBun is designed to help you reduce BUNS. This recipe only works on puzzles with the BUNS objective, and I haven't personally tried it out much, but I've heard a few folks are trying it. Plus, if you're looking to get involved with recipe evolving, this simple recipe could be a good way to get some practice with Lua. Given how important the BUNS objective is, we're going to need more recipes like this! So thanks mwm64 for making the first de-BUN-ifier!

Player of the Week

A quick shout-out this week to malphis, a friendly newcomer who joined a couple of months ago and has been really active in chat. Malphis has also been super helpful submitting bug reports to help the devs track down issues. Thanks!

Art of the Week

Looking for some more protein beauty? Check out this beautiful proteins blog! It's got a ton of real proteins that are naturally amazingly beautiful.

Today’s Master Folding Tips

Beginner: Before trying to wiggle your designed protein into the perfect shape, give it a mutate first! This will help the protein pack together better and give you a cleaner structure to work with. You can also mutate by hand: for example, although all of your amino acids start as isoleucine, it's actually better to set your loops to asparagine to start with.

Intermediate: Have you learned how to use the Rama map yet? We're working on a few new guides that should help make it easier to learn, but in the meantime Susume has two guides on how to use the Rama map to fix un-ideal loops and even copy a loop

Expert: Are you planning your design before you make it? Before you start drafting, spend a few minutes thinking about what your design will look like. How long will each helix and sheet be? Will you try to make pi stacks? What part of the protein will bind at the interface, and how will that give it shape complementarity? Once you're ready, use Loci's AA Edit and SS Edit to enter your design and give it a quick early/midgame rinse. Then hand it off to a novice member of your group to evolve and try another design!

Have a tip to share with the community? Reply with your wisdom, or post on our Forums!

Until next time, happy folding!

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Newsletter July 31: DDG Challenge

Newsletter July 31: DDG Challenge

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1867: Symmetric Trimer Design: Limited Interface 2

Like last week, the top results here used a lot of helical bundles and rotated them to limit the size of the interface.

Puzzle 1868: Coronavirus Binder Design Round 14

Lately, most of the top solutions have been three-helix bundles. This week that's true too, but here are a few good designs that didn't do that! In these images, I pulled the binders out of the binding site so you can get a good look at their shapes. (Some images may be from previous rounds.)

Recipe of the Week

This week's recipe is by Design Models Bruno Kestemont.
This recipe is really great for getting started with an early draft of your design, and is especially useful for all the beginner designers out there! Just click a design, like HHH for triple helix or SSSSHH (4-sheet 2-helix), and it'll automatically assign secondary structures for you based on Bruno's recommended SS lengths. Don't forget to use Ideal SS afterward to see your secondary structures come together!

Player of the Week

A quick shout-out this week to Dudit for being a pal in global chat and a hard worker on the Coronavirus challenges! Dudit has been reaching the top 10 on Coronavirus puzzles pretty consistently. Say hi to them next time you're in chat!

Challenge of the Week

This past week, donuts554 made the first-ever DDG Calculator recipe. For next week, I'm challenging all folders to expand on this idea! Here's Susume's recommended way to determine DDG, which was approved by our scientists as a valid approach:

1. Measure score

2. Freeze everything

3. Use bands to pull the binder far away from the target

4. Unfreeze

5. Shake

6. Wiggle sidechains

7. Report the difference between this score and the old one

(8. Return the protein to its original position!)

Feel free to try your own method, or use Susume's. The best DDG Calculator will be announced as next week's Recipe of the Week!

The devs are hard at work making a DDG objective, but until then, a recipe is a great way to make sure your fold is scientifically great.

Today’s Master Folding Tips

Beginner: Use building blocks from the Blueprint panel to make sure your loops are ideal! Just don't forget to remove these blocks during the late game to squeeze out extra points at the end.

Intermediate: Did you know you can fix un-ideal loops with Remix too? LociOiling made a video about it here!

Expert: How well do you know your Koga & Koga design rules? Be sure to check out their supplements for SS design principles to help make sure your designs are scientifically valid!

Good luck on this week's DDG challenge! Don't forget to share your recipes on our Discord!

Until next time, happy folding!

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Newsletter August 7: Are you making the future of fabric?

Newsletter August 7: Are you making the future of fabric?

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1870: In Which We Continue to Make Trimers of Varying Lengths While Limiting the Size of the Interface Between Symmetric Copies to Avoid Misfolding and Aggregation

Now, you may be thinking to yourself, "This again? Why are we even doing this?" But the answer
is actually super neat! Designing proteins that can bind together in assemblies is the first step of research toward lab-made synthesis of protein-based materials. You're probably familiar with some of these materials: silk, wool, cotton, and leather.

What if humans could design their own materials, to be stronger, more durable, or softer? This is the research you're supporting by designing really cool trimers. So keep it up folders! You're doing awesome, awesome work. (Want to learn more about protein-based materials? For beginners, check out this article.
For experts, try this one.

Can't get enough designs? Each week, players like LociOiling upload their own screenshots to the wiki!

Puzzle 1871: Coronavirus Anti-inflammatory Design 9

Want to see more designs? Check out the wiki!

Recipe of the Week

This week's recipe is Freeze All Sheets by srssmith92. A quick, simple utility useful for the early game!

Our DDG Challenge is still running! Check out last week's newsletter for more info! However, this challenge might end early. Our scientists are almost ready to debut new Objectives that measure DDG for you!

Player of the Week

A quick shout-out this week to Todd6485577. Todd only started in April, but they've been a happy addition to our Foldit family and a friendly voice in chat. Thanks for folding, Todd!

Art of the Week

"Pretty Trimer" comes from Jpilkington, one of the many amazing Gargleblasters! As I write this, the Gargleblasters have the top spots on the leaderboards for this week. Not only have they mastered the puzzles, but they also have the creativity to design wonderful art!

Today’s Master Folding Tips

Beginner:
If you haven't already, join a group and start evolving other players' solutions! It's the best way to train your eye for what a good protein looks like!

Intermediate:
Natural sheets don't always line up perfectly. In fact, a neighboring sheet is usually a little bit shorter or longer!

Expert:
How do you decide what amino acids should go in your loops? This paper by Lin et al. found some correlations between amino acids and loop types. Check it out!

Do you have the creativity to make art from science? Post your pretty proteins on our Discord!

Until next time, happy folding!

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Newsletter August 14: The New Binder Metrics Are Here!

Newsletter August 14: The New Binder Metrics Are Here!

Hey folders!

Dev Josh here with your weekly Foldit update. The new binder metrics are finally here! This devprev* puzzle tests out DDG, SASA, and Shape Complementarity. Not sure what binder metrics are? Check bkoep's blog post here.

*Devprev is Foldit's beta testing version. May contain bugs. Want to try it anyway? Find the options.txt file in your Foldit folder and change "update_group" from "main" to "devprev" -- you can always change it back when you want to go to a stable build again!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1873: Symmetric Trimer Design: Limited Interface

Most of these solutions were triple helices, but take a look at the one that isn't: it's got some very neat pi interactions, also known as pi stacking.

Puzzle 1874: Coronavirus Binder Design: Round 15

If you guessed triple helices would be the top solutions of this week's coronavirus puzzles, you'd be right! Seriously, if you're new and just want to get something to work, give triple helix a shot.

Recipe of the Week

This week's recipe is Quickfix, a popular mid game refinement tool by spvincent and Bruno Kestemont. Have an issue, need a quick fix? Try Quickfix!

Player of the Week

A huge hoorah to Boots McGraw for being a star returning to the Foldit community. Back in the day, Boots was such a great player that he even won a Foldit trophy for having the first-ever player design tested in the lab! Now, after six years of what I can only imagine was a pursuit to become the best in something else, Boots has returned with vigor and vim, reaching the global top 10 in only four months of getting back into his folding groove. I'm sure his team, the Contenders, are very glad to see him back. Welcome back Boots (and his faithful equine companion, Trigger!), we hope to have you here for many more years to come.

Today’s Master Folding Tips

Beginner: Never wiggle at full Clashing Importance if there are still clashes around, otherwise everything will fly apart!

Intermediate: Having trouble building a core? Try wiggling at low CI (around 0.3-0.4), then mutate at full CI, followed by a wiggle. The low CI wiggle brings everything together, then the high CI mutate lets Foldit pick smaller sidechains for the core to bring the backbones closer together. (If you'd rather have larger sidechains, mutate at a lower CI.) Thanks to Susume and tokens for this tip!

Expert: Given a particular sheet length, the helix length to cover it in a sheet-helix-sheet motif doesn't vary much. The chirality stays the same, too. No need to play with these designs, sheet-helix-sheet motifs are pretty consistent!

If you have the time, putting a video of Foldit on YouTube is a really, really great way to help share tips with the community and get new players interested in the game. There's some resources for making videos and livestreaming Foldit on this wiki page.

Until next time, happy folding!

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Newsletter August 21: All About Those HBNets

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1876: Symmetric Trimer Design: H-Bond Networks

Take a look at all the different ways folks were making h-bond networks this time!

Puzzle 1877: Coronavirus Anti-inflammatory Design 10

These puzzles will soon be shaken up as the new binder metrics come out! Check out LociOiling's new wiki pages on DDG and SASA to get a head start on how to master these metrics!

Recipe of the Week

This week's recipe is just for fun: Zo3xia has put the ancient game of Go inside Foldit! Need a quick mini-game? Play the AI in a 2x2 version of this classic Chinese strategy game. Download the recipe here!

Player of the Week

A big thank you to spvincent this week for making a new wiki page on how to make h-bond networks! Want to play with spvincent's expert HBNets? Join the Contenders and evolve their solutions!

Today’s Master Folding Tips

Beginner: Try setting the Clashing Importance to 0 when pulling stuff around. Things will fly apart a lot less!

Intermediate: Here are some advanced camera controls that often go unnoticed: you can fade the lighting ("fog") on the protein by holding Ctrl + Alt/Option + left click and dragging. Or you can clip the background entirely by holding Ctrl + Shift + left click and dragging. You can clip the foreground by holding Ctrl + Alt/Option + left click and dragging. In combination with using Q to focus on a residue, these controls let you see just the part of your protein that you're trying to focus on.

Expert: Check out this article on small beta barrels!

Want to improve your folding? Click the camera button in the chat box to post a screenshot of your design in global chat and ask for feedback!

Until next time, happy folding!

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Newsletter August 28: Gargleblasters Take the Lead!

Hey folders!

Dev Josh here with your weekly Foldit update. Congratulations to the Gargleblasters for getting the top rank in this week's puzzles! Great job Jpilkington and Skippysk8s for taking the #1 spots! If you'd like to join Gargleblasters, send a private message to Skippysk8s.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1879: Symmetric Trimer Design: H-Bond Networks

We saw some really cool designs this round! I have no idea how likely these folds are to fold up well, but gosh are they pretty!

Puzzle 1880: Coronavirus Binder Design 16

This round of the Coronavirus puzzles introduced the new binder metrics! They're slow to run, so it's best to only run them after major changes. This week I'm showing results in AAColor so you can get a better sense of what amino acids are being used in these helices!

Recipe of the Week

Looking for something to help you make better H-bond networks? Try HNetwork Probe by spvincent!

Player of the Week

This week's player of the week is donuts554! Not only is donuts always a friendly voice in chat, they made a detailed strategy guide on the wiki describing how they approach Foldit. Thanks for being a part of the community, donuts :)

Art of the Week

Here are some mesmerizing folds by Formula350. Very cool!

Today’s Master Folding Tips

Beginner: Having trouble getting started on design puzzles? Those extended chains can be intimidating when your protein is just one straight line. Bruno's Design Models recipe is a great way to start drafting your fold early on! Run this recipe, then use Ideal SS on each structure and you'll be halfway to having something foldable!

Intermediate/Expert: This week the advice for intermediate and expert players is the same because of how important it is. Take notes! For each puzzle you play, jot down some quick notes on how you tackled it. How did you decide what to do in the early game? What recipes did you run? What was challenging? Journaling is an awesome, invaluable strategy for getting better because it lets you reflect on what you've already done and what you can try next time. Bonus points if you share your notes with the rest of the community! Make a forum post or a wiki page, or just post on the Discord in the #tips-and-tricks channel. Let us know what you discover or what patterns you observe. We don't have time to make all the mistakes ourselves, so tell us what you struggled with and how you got through it so that we can learn too!

Have a good or interesting solution to share? Don't forget to click the Upload For Scientists button in the Open/Share Solutions menu!

Until next time, happy folding!

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Newsletter September 4: School's In Session!

Hey folders!

Dev Josh here with your weekly Foldit update. This week the scientists shared LCB1 with us: a protein designed by the IPD that binds to the coronavirus spike protein to block viral infection. Bkoep talked about it more in this month's lab report. Check it out and learn how the scientists are tackling the same folding problem as you!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1882: Symmetric Trimer Design: H-Bond Networks

Puzzle 1883: Coronavirus Anti-inflammatory Design: Round 11

Recipe of the Week

This week's recipe is an update on a classic: Blue Fuse 2020. Blue Fuse is one of the best recipes of all time, and LociOiling has updated it for modern use. Blue Fuse automates the process of shaking and wiggling while slowly increasing the clashing importance: a great tool for stabilizing your fold!

Player of the Week

Big thanks to jeff101 this week for always being helpful to new players in global chat, especially now as Education mode is helping students this semester! And thanks to all of our veteran folders who help newcomers learn to fold. You rock!

Today’s Master Folding Tips

Beginner: Having trouble getting the protein where you need it to go? Try turning the clashing importance to 0 to pull things easier without unintended consequences. Or use the Cut and Move technique!

Intermediate: Your eyes play tricks on you! Don't forget to keep moving your camera around to see the 3D shape of your fold. Try going into Sphere view and Stick view to get different perspectives on the shape of your protein as well!

Expert: Did you know that the orientation of donors and acceptors is important for forming good hydrogen bonds? Check out the cheat sheet below, courtesy of uihcv!

Want to learn more about the science of Foldit? Check out Foldit Education mode!

Until next time, happy folding!

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Newsletter September 11: Y'all Are Maaad Good at This Game

Hey folders!

Dev Josh here with your weekly Foldit update. And, just because I don't say this enough, thanks for playing everybody. You impress me every week with your creativity, persistence, and commitment to contributing to science, and I think I speak for all of the scientists when I say we really, really appreciate your efforts.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1884: Refinement Target R1056

Here's a full look at one of the best solutions for this refinement puzzle.

Puzzle 1885: Symmetric Trimer Design: H-Bond Networks

Puzzle 1886: Coronavirus Binder Design 17

Recipe of the Week

This week's recipe is Ma-a-a-ad good! Check out Maaa by Bruno Kestemont to "Mutate Authorized Amino Acids." Unlike the standard Mutate tool, which tries every amino acid possibility, with Bruno's Maaa, you can deny and allow specific amino acid mutations. This is great for preserving your orange hydrophobics or mutating explicitly for making hydrogen bonds.

Player of the Week

Shoutout to HuubR for being a big help in chat this week!

Today’s Master Folding Tips

Beginner: Having trouble with the tutorials? Check out this tutorial guide by S0ckrates! Or check the wiki for walkthroughs! Or ask questions in chat, there's lots of friendly folks happy to help you!

Intermediate: Having lots of candy cane colored hydrogen bonds is nice, but good packing is better. Rather than trying to make hydrogen bonds appear, focus on satisfying as many polar groups as you can and aligning the bond angles for strong connections. (This tip courtesy of uihcv, thanks!)

Expert: Sometimes the best way to learn is to teach. Take a look at your group's shares and try to evolve it by hand, consciously. Think about why you're making the changes you're making, and leave notes on what you did and why. Share it back with the original creator and talk to them about what you did to improve their design. You might learn a thing or two from the process!

Want more tips and news? Subscribe to our YouTube channel and click the bell icon so you get notified when our lab reports go live!

Until next time, happy folding!

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Newsletter September 18: Coming Up Roses

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1888: Symmetric Trimer Design: H-Bond Networks

Puzzle 1889: Coronavirus Anti-inflammatory Design 12

Recipe of the Week

This week's recipe is one of Rav3n_pl's GAB recipes, cleaned up by Bruno Kestemont. Try it out for some mid to late game improvements!

Player of the Week

A big Foldit welcome to Jumper2, one of our newest folders who has been great company in chat and a big help in providing feedback on the Discord. Jumper2 is one of the newest members of Gargleblasters. Thanks for folding with us!

Art of the Week

This week's art is titled "Bouquet of Roses" by BootsMcGraw. Not only is this four-helix design pretty, it's one of the top scoring solutions of puzzle 1888! Great job Boots! Want to fold with the famous cowboy of Foldit? Join the Contenders!

Today’s Master Folding Tips

Beginner: Are your loops too long? Most loops in the top Foldit designs are 5 residues or shorter! Bruno's Design Models is also a great way to get started with a design!

Intermediate: Challenge yourself to try something new every puzzle! Try a new recipe or a new strategy every time. Don't forget to write down what you did to collect notes on what worked and what didn't!

Expert: Want to shift an end residue to the other end? Here's a tip from Timo and Susume: 1) Use AA Edit to copy out your amino acid sequence; 2) Set your whole protein to be one long sheet; 3) Use tweak to flip the sheet once; 4) Use AA Edit again with your residue shifted to the other end to reapply your AA sequence how you want it. (Presumably, you also return your SS to how you want it!) Thanks Timo and Susume for the tip!

Don't forget to follow us on Twitter for the latest updates on your favorite protein-based game through your favorite bird-based social media platform!

Until next time, happy folding!

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Newsletter September 25: Raspberry Remix

Hey folders!

Dev Josh here with your weekly Foldit update. Got a Raspberry Pi and want to run Foldit on it? Check out this player's guide on our forums!

Solutions from This Week's Puzzles

Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1890: Revisiting Puzzle 136: Cell Adhesion

Puzzle 1891: Symmetric Trimer Design: H-bond Networks

Puzzle 1892: Coronavirus Binder Design: Round 18

Recipe of the Week

This week's recipe is the classic Deep Remix Worst by Timo van der Laan, or TvdL's DRemixW for short. This great late game recipe can help remix your design automatically, especially if you give it a few hours or even overnight.

Player of the Week

Shoutout to aqsw, one of the new folders for Go Science, for being so welcoming in the Foldit Discord! Glad to have you folding with us, aqsw!

Today’s Master Folding Tips

Beginner: Tired of wiggling all the time? Try running a recipe like this one!

Intermediate: Practice your hand-folding by challenging yourself to not run any recipes until late game!

Expert: You might know that the Blueprint tool adds torsional constraints, which is why you want to take them off during the late game. But did you know that those constraints are different than the ones the Blueprint starts in? Each Blueprint block has "adjusted" torsions so that things lock into place nicely when you're constructing a backbone from scratch. Then the torsional constraints help
bring things back into ideality the next time you wiggle. For example, if you made two ideal helices in Foldit and used an un-adjusted ideal AGBBA loop, the ideal helices would not align parallel to one another -- they would flare off at a skew angle. Usually we want the helices to be parallel to each other, but this requires some tiny adjustments to "perfect ideality".
For more on the Blueprint tool, check out this blog post!

Missed this week's Office Hours? Check the transcripts here! Don't forget to give us feedback on them! Did we answer all of your questions? Do you want Office Hours to be something different? Let us know!

Until next time, happy folding!

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Newsletter October 2: It's Fall Y'all

Hey folders!

Dev Josh here with your weekly Foldit update. Happy October! And Chag Sameach to all of our Jewish folders playing on this week of Sukkot.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1894: Symmetric Trimer Design: H-Bond Networks

Puzzle 1895: Coronavirus Anti-inflammatory Design 13

Recipe of the Week

Do you enjoy running TvdL's DRemixW but wish that it stopped turning your hydrophobics into hydrophilics? Try Susume's Orange Guard version! Just freeze your hydrophobics before you run it, and this DRemixW variant will only mutate those residues into other hydrophobics. Thanks Susume!

Player of the Week

A quick shout-out today to Jumper2, one of the newest members of Gargleblasters and a welcome addition to the Foldit family! Thanks for all of your great questions and feedback!

Art of the Week

This week's art was made by malphis. Cool stuff! Want to make your own Foldit art? Post your screenshots on the Foldit Discord! This month's theme is: Pumpkins!

Today’s Master Folding Tips

Beginner: Challenge yourself to get 9,000 points on all of the Beginner puzzles! Then 10,000, then 11,000! Ask for help in chat if you get stuck on how you can make improvements, and share screenshots with the camera button.

Intermediate: Want to get a better SASA score for binder puzzles like Coronavirus? Try bander recipes, like Blue Fuse or Quake. Thanks nspc for the tip!

Expert: Here's a handy cheat sheet for ideal loops in the Rama map, courtesy of uihcv! Notice that one of the loops (Helix-Helix; red green blue blue red) has the second (green) residue in an unsatisfactory region. Curious why that is? Check out last week's expert tip to find out!

Missed this month's Lab Report? Check it out here! And don't forget to come to next week's Office Hours with Dr. Scott Horowitz, on Friday Oct. 9 at 19:30 UTC (12:30pm PT; 3:30pm ET) in #veteran chat, or on the Foldit Discord!

Until next time, happy folding!

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Newsletter October 9: Making a Tri-Dent in Coronavirus

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1897: Symmetric Trimer Design: H-Bond Networks

Look at all these great sheets! Coloring in CPK.

Puzzle 1898: Coronavirus Binder Design: Round 19

Triple helix is still the best way to go, but how do you attach? Here are some top scoring examples! Coloring in ABEGO.

Recipe of the Week

Looking for something new to shake out your design draft in the early game? Try this recipe by Bruno Kestemont! A few mutates, some shakes and wiggles, you can't go wrong!

Player of the Week

A big thanks to JoannaH for folding with us since 2010! Joanna was the top scorer for Coronavirus Binder Design Round 19 and currently holds the top spot in this week's Anti-Inflammatory Design Round 14! Plus, she's just a great person to talk to. Say hi next time you see her in chat!

Art of the Week

This week's art comes to us from Formula350: "Poseidon's Trident". Nice one, Formula!

Today’s Master Folding Tips

Beginner: Did you know you can band the protein to empty space? Drag a band from the protein to any point in space to create a zero-length band ("ZLB"), also known as a spaceband. This band will try to hold that part of the protein exactly where you point it to in 3D space!

Intermediate: Having trouble with BUNS? Try hand-folding them into a better position in the mid-game, then freeze them where they are while the BUNS are resolved for your late game refinement.

Expert: Don't forget to update your recipes with these latest versions! HNetwork Probe 2.1 by spvincent, Design Models 2.3.3 by Bruno Kestemont, and Simulated Annealing 5.0 by KarenCH just came out this week!

Have a question about the science of Foldit? Ask it in our #science channel on Discord!

Until next time, happy folding!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons