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Here are all the Foldit newsletters that have been sent out, with the most recent one at the bottom.

If you have questions on any of these newsletters, please feel free to contact mail.fold.it@gmail.com or ask them in Discord.

Additionally, if you would like to sign up for our mailing list to receive these newsletters, please click here!

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Newsletter July 3: Initial Reactions

Newsletter July 3: Initial Reactions

Hey folders!

Dev Josh here with your weekly Foldit update.

This week we saw the introduction of the Reaction Design tool. The devs are working hard on polishing it up and making it more usable! As always, thanks for your feedback and bug reports. You can submit more feedback here.

Top Results from Puzzle 1856: Coronavirus Round 12

In this puzzle, I accidentally evo'ed on a broken developer build and got the top score. Whoops, sorry about that!
Here are some of the solutions at the top of the leaderboards. [A note from our scientists: the top of the leaderboards doesn't always mean the most scientifically useful. These highlights are not scientific feedback and are not officially endorsed as scientifically valid designs by the Foldit team.]

Join the mailing list to see what others are folding!

Recipe of the Week

This week's recipe is an oldie but a goodie from drjr. The recipe is called Reset, and it does what it says on the tin: reset to the best score, unfreeze the protein, remove all your bands, and set the CI to 1. A simple recipe, but a handy quality of life tool for when you just need to backtrack a little.

Player of the Week

Quick shoutout to argyrw for always being a friendly voice in chat! Say hi to her in global or veteran chat.

Today’s Master Folding Tips

Beginner: Are you still using Pull to draft your protein in the early game? Try making cutpoints and moving pieces around with the Move tool, it's so much easier! Don't forget to disable cutpoint bands in the Behavior tab, or they'll all come together again when you wiggle.

Intermediate: It can be really tempting mid-game to just switch to running recipes. But give some time to carefully inspect every acceptor and donor (the red and blue dots) to see what hydrogen bonds you can form, and manually mutate as needed. Not only will this lower your BUNS, but it'll help form a strong hbond network. The scientists love this, and your rank will too!

Expert: If you haven't already, read bkoep's blog on binder design metrics. DDG, SASA, and SC are going to become really important soon since we're looking to add objectives for them. So understanding and practicing these principles now can help you get a headstart on the competition! Use the protein design sandbox to try out some ideas.

Have a tip to share or a recipe to recommend? Reply with your suggestions or make a wiki page for your ideas! Reaction Design doesn't have a page yet, so if you understand this tool, help out your community by writing about it! (Since writing this post, LociOiling has graciously created the page for Reaction Design puzzles.)

Until next time, happy folding!

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Newsletter July 10: Triple-Quad Helices and Borromean Rings

Newsletter July 10: Triple-Quad Helices and Borromean Rings

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1858: Symmetric Trimer Design

Personally, I went with a 4-helix design for this puzzle, and it seems like that's what a lot of the highest scoring solutions did. But there were also a couple of 3-helix designs, and even some sheets!

Puzzle 1860: Refinement R1040

The highest scoring solutions for this puzzle kept two medium-sized sheets lined up and folded the rest into short helices around a core.

Compare this to some of the intermediate solutions. Although these folds are okay, they had some minor problems: some loose helices and poor scoring ends.

What was the trickiest part for you about this puzzle? Let's talk about it in Discord!

Recipe of the Week

This week's recipe has been described by Phyx as "The Best Recipe of 2014": Wisky's Repeating Rebuild All!

Let this late-game recipe run for 3-4 hours and it will do some rebuilding magic on your pose.

Player of the Week

I want to honor LociOiling! for constantly being the #1 contributor to our wiki!. This week he created the pages for Reaction Design Puzzles and Camera Controls! If you've ever read a wiki page that was made in the last few years, chances are Loci wrote it. Give him your thanks in chat next time you use the wiki!

Art of the Week

This week's most beautiful fold comes from Formula350 for his Borromean rings! This would never fold up in real life, but wow, is it pretty!

Today’s Master Folding Tips

Beginner: Don't be afraid to reassign your secondary structures to different sheets and helices! While this might seem like you're "changing the puzzle," you're really just making a suggestion for what shape the protein should take, and this suggestion can help your other tools better serve you. Try a bunch of different secondary structure assignments and use Ideal SS on them afterward, then see how this new arrangement might be easier or harder to fold. Play around with it, Foldit is about experimenting!

Intermediate: If you haven't learned to use Backbone Pins yet, I highly recommend it. This tool, hidden away in the view options, gives you more control over wiggling than CI alone. A locked pin is similar to a ZLB, it will keep your wiggle locked to that spot, while moving everything else more.

Expert: Although it might seem like more hbonds means better binding, hbonds at the interface don't actually add to the strength of the bind, since they aren't much stronger than these atoms simply binding to water. What use are interface hbonds then? Their purpose is eliminating BUNS. The real strength of your binding comes from hydrophobic interactions, shown in the Hiding and Packing subscores, and your hbond network gives the bind its specificity.

Want to recommend a recipe of the week or have your solution featured in the next newsletter? Send us your cookbooks and screenshots, we'd love to see what you're up to!

Until next time, happy folding!

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Newsletter July 17: Bonjour Encore Triple Hélice

Newsletter July 17: Bonjour Encore Triple Hélice

Hey folders!

Dev Josh here with your weekly Foldit update.

3 Solutions from This Week's Puzzle

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1861: Symmetric Trimer Design: Buried Unsats

Triple helix is here to stay, look how clean and neat these bundles are! Great job silent gene and Spvincent

This solution took a less common approach to the triple helix meta. I'll let you decide for yourself whether you think it scored well or not. What do you think of it? Let us know in the Discord!

Puzzle 1862: Coronavirus Round 13

An extra special congratulations goes to clark92 for being top rank for this puzzle! This up-and-coming folder only started folding at the end of February, and already they've taken the leaderboards by storm!

These solutions come from some of our beginner folders! Can you tell what they could do better?

As a reminder, here are some helpful tips from bkoep on designing a good binder!

Want to get your top solution featured in the weekly newsletter? Click the "Share with Scientists" button in the "Open/Share Solution" menu and your solution might get featured! Don't forget to fill out our username sharing form if you'd like your username to be shown with your solutions!

Recipe of the Week

Not sure what recipes are good? Check out this all-in-one recipe: Constructor by Grom!
This mini-cookbook contains 19 different recipes all packed in one. Check it out for some inspiration this week!

Player of the Week

Big thanks to nspc this week for putting out two new French tutorial videos on how to get started with design puzzles and prediction puzzles.

If you're still on the intro puzzles, nspc also has a video on beating Hydrophobic Disaster.

I think I speak for everyone when I say merci beaucoup! Nspc (pc on Discord) is a beginner folder who has been learning fast by being really active in the chat. Say hi next time you see them around!

Art of the Week

Here's some art from 1861: a cool-looking triangle and a crazy ball of... I don't even know what... Thanks for sharing!

Today’s Master Folding Tips

Beginner: Despite how common they are, I really recommend trying a helix bundle like the ones you've seen from the top-scoring solutions! Helices are easier to make than loops or sheets, so practicing on helix bundles is a great way to get a higher rank and practice the basics before trying something tricky and advanced like long loops or a sheet structure.

Intermediate: Are you paying attention to which structures your AA structure preferences. AAs prefer to be in? It's not a hard-and-fast rule, but check out the wiki for AA structure preferences. I find this especially helpful for getting started by mutating my isoleucines away into something more suitable for the structure I'm designing, like asparagines for loops, valines for sheets, and MALEK for helices.

Expert: How many structural motifs can you name? Most of you know pi stacking, some of you even know about beta hairpins. But do you know about ST turns, Greek keys, and Omega loops? What about sequence motifs?

Having these concepts in your toolkit will give you more conceptual legos from natural proteins to think about when designing. There's plenty of research out there on common patterns, and if you're looking for expert tips, then you're ready to dig into real literature. Good luck, and let us know what you find on
Discord

Want to give your group a shoutout in the next newsletter? Reply with a blurb about what your group is and why new players should join, and your group might get featured in the next newsletter!

Until next time! Happy folding!

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Newsletter July 24: A Good Week for Go Science

Newsletter July 24: A Good Week for Go Science

Hey folders!

Dev Josh here with your weekly Foldit update. Congratulations to Go Science! for being the top of all three puzzles this week! Go Science has been an open and active group since 2010. One of the best ways to learn and improve in Foldit is to join a group.

If Go Science isn't your style, try the hopeful and determined Anthropic Dreams, the fun and light Gargleblasters, or the dedicated Contenders

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1863: Refinement R1043

I've heard this puzzle was crashing pretty frequently. Thanks for your patience everyone, the devs are hard at work trying to fix these issues!

Puzzle 1864: Symmetric Trimer Design: Limited Interface

To master this puzzle, you needed to limit how big your binding interface was. Notice how the top scores rotated their helical bundles to limit their attachments!

Puzzle 1865: Coronavirus Anti-inflammatory Design 8

Bkoep said there were 15 unsolvable BUNS, but some of the top solutions got them down to 11! Great job on satisfying those BUNS everyone, keep it up!

Want to know more about why we're designing binders from scratch? Check out this forum thread for details on why we're not just using the ACE2 receptor design.

Recipe of the Week

This week's recipe is new but with great potential:
mwm64's UnBun is designed to help you reduce BUNS. This recipe only works on puzzles with the BUNS objective, and I haven't personally tried it out much, but I've heard a few folks are trying it. Plus, if you're looking to get involved with recipe evolving, this simple recipe could be a good way to get some practice with Lua. Given how important the BUNS objective is, we're going to need more recipes like this! So thanks mwm64 for making the first de-BUN-ifier!

Player of the Week

A quick shout-out this week to malphis, a friendly newcomer who joined a couple of months ago and has been really active in chat. Malphis has also been super helpful submitting bug reports to help the devs track down issues. Thanks!

Art of the Week

Looking for some more protein beauty? Check out this beautiful proteins blog! It's got a ton of real proteins that are naturally amazingly beautiful.

Today’s Master Folding Tips

Beginner: Before trying to wiggle your designed protein into the perfect shape, give it a mutate first! This will help the protein pack together better and give you a cleaner structure to work with. You can also mutate by hand: for example, although all of your amino acids start as isoleucine, it's actually better to set your loops to asparagine to start with.

Intermediate: Have you learned how to use the Rama map yet? We're working on a few new guides that should help make it easier to learn, but in the meantime Susume has two guides on how to use the Rama map to fix un-ideal loops and even copy a loop

Expert: Are you planning your design before you make it? Before you start drafting, spend a few minutes thinking about what your design will look like. How long will each helix and sheet be? Will you try to make pi stacks? What part of the protein will bind at the interface, and how will that give it shape complementarity? Once you're ready, use Loci's AA Edit and SS Edit to enter your design and give it a quick early/midgame rinse. Then hand it off to a novice member of your group to evolve and try another design!

Have a tip to share with the community? Reply with your wisdom, or post on our Forums!

Until next time, happy folding!

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Newsletter July 31: DDG Challenge

Newsletter July 31: DDG Challenge

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1867: Symmetric Trimer Design: Limited Interface 2

Like last week, the top results here used a lot of helical bundles and rotated them to limit the size of the interface.

Puzzle 1868: Coronavirus Binder Design Round 14

Lately, most of the top solutions have been three-helix bundles. This week that's true too, but here are a few good designs that didn't do that! In these images, I pulled the binders out of the binding site so you can get a good look at their shapes. (Some images may be from previous rounds.)

Recipe of the Week

This week's recipe is by Design Models Bruno Kestemont.
This recipe is really great for getting started with an early draft of your design, and is especially useful for all the beginner designers out there! Just click a design, like HHH for triple helix or SSSSHH (4-sheet 2-helix), and it'll automatically assign secondary structures for you based on Bruno's recommended SS lengths. Don't forget to use Ideal SS afterward to see your secondary structures come together!

Player of the Week

A quick shout-out this week to Dudit for being a pal in global chat and a hard worker on the Coronavirus challenges! Dudit has been reaching the top 10 on Coronavirus puzzles pretty consistently. Say hi to them next time you're in chat!

Challenge of the Week

This past week, donuts554 made the first-ever DDG Calculator recipe. For next week, I'm challenging all folders to expand on this idea! Here's Susume's recommended way to determine DDG, which was approved by our scientists as a valid approach:

1. Measure score

2. Freeze everything

3. Use bands to pull the binder far away from the target

4. Unfreeze

5. Shake

6. Wiggle sidechains

7. Report the difference between this score and the old one

(8. Return the protein to its original position!)

Feel free to try your own method, or use Susume's. The best DDG Calculator will be announced as next week's Recipe of the Week!

The devs are hard at work making a DDG objective, but until then, a recipe is a great way to make sure your fold is scientifically great.

Today’s Master Folding Tips

Beginner: Use building blocks from the Blueprint panel to make sure your loops are ideal! Just don't forget to remove these blocks during the late game to squeeze out extra points at the end.

Intermediate: Did you know you can fix un-ideal loops with Remix too? LociOiling made a video about it here!

Expert: How well do you know your Koga & Koga design rules? Be sure to check out their supplements for SS design principles to help make sure your designs are scientifically valid!

Good luck on this week's DDG challenge! Don't forget to share your recipes on our Discord!

Until next time, happy folding!

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Newsletter August 7: Are you making the future of fabric?

Newsletter August 7: Are you making the future of fabric?

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1870: In Which We Continue to Make Trimers of Varying Lengths While Limiting the Size of the Interface Between Symmetric Copies to Avoid Misfolding and Aggregation

Now, you may be thinking to yourself, "This again? Why are we even doing this?" But the answer
is actually super neat! Designing proteins that can bind together in assemblies is the first step of research toward lab-made synthesis of protein-based materials. You're probably familiar with some of these materials: silk, wool, cotton, and leather.

What if humans could design their own materials, to be stronger, more durable, or softer? This is the research you're supporting by designing really cool trimers. So keep it up folders! You're doing awesome, awesome work. (Want to learn more about protein-based materials? For beginners, check out this article.
For experts, try this one.

Can't get enough designs? Each week, players like LociOiling upload their own screenshots to the wiki!

Puzzle 1871: Coronavirus Anti-inflammatory Design 9

Want to see more designs? Check out the wiki!

Recipe of the Week

This week's recipe is Freeze All Sheets by srssmith92. A quick, simple utility useful for the early game!

Our DDG Challenge is still running! Check out last week's newsletter for more info! However, this challenge might end early. Our scientists are almost ready to debut new Objectives that measure DDG for you!

Player of the Week

A quick shout-out this week to Todd6485577. Todd only started in April, but they've been a happy addition to our Foldit family and a friendly voice in chat. Thanks for folding, Todd!

Art of the Week

"Pretty Trimer" comes from Jpilkington, one of the many amazing Gargleblasters! As I write this, the Gargleblasters have the top spots on the leaderboards for this week. Not only have they mastered the puzzles, but they also have the creativity to design wonderful art!

Today’s Master Folding Tips

Beginner:
If you haven't already, join a group and start evolving other players' solutions! It's the best way to train your eye for what a good protein looks like!

Intermediate:
Natural sheets don't always line up perfectly. In fact, a neighboring sheet is usually a little bit shorter or longer!

Expert:
How do you decide what amino acids should go in your loops? This paper by Lin et al. found some correlations between amino acids and loop types. Check it out!

Do you have the creativity to make art from science? Post your pretty proteins on our Discord!

Until next time, happy folding!

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Newsletter August 14: The New Binder Metrics Are Here!

Newsletter August 14: The New Binder Metrics Are Here!

Hey folders!

Dev Josh here with your weekly Foldit update. The new binder metrics are finally here! This devprev* puzzle tests out DDG, SASA, and Shape Complementarity. Not sure what binder metrics are? Check bkoep's blog post here.

*Devprev is Foldit's beta testing version. May contain bugs. Want to try it anyway? Find the options.txt file in your Foldit folder and change "update_group" from "main" to "devprev" -- you can always change it back when you want to go to a stable build again!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1873: Symmetric Trimer Design: Limited Interface

Most of these solutions were triple helices, but take a look at the one that isn't: it's got some very neat pi interactions, also known as pi stacking.

Puzzle 1874: Coronavirus Binder Design: Round 15

If you guessed triple helices would be the top solutions of this week's coronavirus puzzles, you'd be right! Seriously, if you're new and just want to get something to work, give triple helix a shot.

Recipe of the Week

This week's recipe is Quickfix, a popular mid game refinement tool by spvincent and Bruno Kestemont. Have an issue, need a quick fix? Try Quickfix!

Player of the Week

A huge hoorah to Boots McGraw for being a star returning to the Foldit community. Back in the day, Boots was such a great player that he even won a Foldit trophy for having the first-ever player design tested in the lab! Now, after six years of what I can only imagine was a pursuit to become the best in something else, Boots has returned with vigor and vim, reaching the global top 10 in only four months of getting back into his folding groove. I'm sure his team, the Contenders, are very glad to see him back. Welcome back Boots (and his faithful equine companion, Trigger!), we hope to have you here for many more years to come.

Today’s Master Folding Tips

Beginner: Never wiggle at full Clashing Importance if there are still clashes around, otherwise everything will fly apart!

Intermediate: Having trouble building a core? Try wiggling at low CI (around 0.3-0.4), then mutate at full CI, followed by a wiggle. The low CI wiggle brings everything together, then the high CI mutate lets Foldit pick smaller sidechains for the core to bring the backbones closer together. (If you'd rather have larger sidechains, mutate at a lower CI.) Thanks to Susume and tokens for this tip!

Expert: Given a particular sheet length, the helix length to cover it in a sheet-helix-sheet motif doesn't vary much. The chirality stays the same, too. No need to play with these designs, sheet-helix-sheet motifs are pretty consistent!

If you have the time, putting a video of Foldit on YouTube is a really, really great way to help share tips with the community and get new players interested in the game. There's some resources for making videos and livestreaming Foldit on this wiki page.

Until next time, happy folding!

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Newsletter August 21: All About Those HBNets

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1876: Symmetric Trimer Design: H-Bond Networks

Take a look at all the different ways folks were making h-bond networks this time!

Puzzle 1877: Coronavirus Anti-inflammatory Design 10

These puzzles will soon be shaken up as the new binder metrics come out! Check out LociOiling's new wiki pages on DDG and SASA to get a head start on how to master these metrics!

Recipe of the Week

This week's recipe is just for fun: Zo3xia has put the ancient game of Go inside Foldit! Need a quick mini-game? Play the AI in a 2x2 version of this classic Chinese strategy game. Download the recipe here!

Player of the Week

A big thank you to spvincent this week for making a new wiki page on how to make h-bond networks! Want to play with spvincent's expert HBNets? Join the Contenders and evolve their solutions!

Today’s Master Folding Tips

Beginner: Try setting the Clashing Importance to 0 when pulling stuff around. Things will fly apart a lot less!

Intermediate: Here are some advanced camera controls that often go unnoticed: you can fade the lighting ("fog") on the protein by holding Ctrl + Alt/Option + left click and dragging. Or you can clip the background entirely by holding Ctrl + Shift + left click and dragging. You can clip the foreground by holding Ctrl + Alt/Option + left click and dragging. In combination with using Q to focus on a residue, these controls let you see just the part of your protein that you're trying to focus on.

Expert: Check out this article on small beta barrels!

Want to improve your folding? Click the camera button in the chat box to post a screenshot of your design in global chat and ask for feedback!

Until next time, happy folding!

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Newsletter August 28: Gargleblasters Take the Lead!

Hey folders!

Dev Josh here with your weekly Foldit update. Congratulations to the Gargleblasters for getting the top rank in this week's puzzles! Great job Jpilkington and Skippysk8s for taking the #1 spots! If you'd like to join Gargleblasters, send a private message to Skippysk8s.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1879: Symmetric Trimer Design: H-Bond Networks

We saw some really cool designs this round! I have no idea how likely these folds are to fold up well, but gosh are they pretty!

Puzzle 1880: Coronavirus Binder Design 16

This round of the Coronavirus puzzles introduced the new binder metrics! They're slow to run, so it's best to only run them after major changes. This week I'm showing results in AAColor so you can get a better sense of what amino acids are being used in these helices!

Recipe of the Week

Looking for something to help you make better H-bond networks? Try HNetwork Probe by spvincent!

Player of the Week

This week's player of the week is donuts554! Not only is donuts always a friendly voice in chat, they made a detailed strategy guide on the wiki describing how they approach Foldit. Thanks for being a part of the community, donuts :)

Art of the Week

Here are some mesmerizing folds by Formula350. Very cool!

Today’s Master Folding Tips

Beginner: Having trouble getting started on design puzzles? Those extended chains can be intimidating when your protein is just one straight line. Bruno's Design Models recipe is a great way to start drafting your fold early on! Run this recipe, then use Ideal SS on each structure and you'll be halfway to having something foldable!

Intermediate/Expert: This week the advice for intermediate and expert players is the same because of how important it is. Take notes! For each puzzle you play, jot down some quick notes on how you tackled it. How did you decide what to do in the early game? What recipes did you run? What was challenging? Journaling is an awesome, invaluable strategy for getting better because it lets you reflect on what you've already done and what you can try next time. Bonus points if you share your notes with the rest of the community! Make a forum post or a wiki page, or just post on the Discord in the #tips-and-tricks channel. Let us know what you discover or what patterns you observe. We don't have time to make all the mistakes ourselves, so tell us what you struggled with and how you got through it so that we can learn too!

Have a good or interesting solution to share? Don't forget to click the Upload For Scientists button in the Open/Share Solutions menu!

Until next time, happy folding!

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Newsletter September 4: School's In Session!

Hey folders!

Dev Josh here with your weekly Foldit update. This week the scientists shared LCB1 with us: a protein designed by the IPD that binds to the coronavirus spike protein to block viral infection. Bkoep talked about it more in this month's lab report. Check it out and learn how the scientists are tackling the same folding problem as you!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1882: Symmetric Trimer Design: H-Bond Networks

Puzzle 1883: Coronavirus Anti-inflammatory Design: Round 11

Recipe of the Week

This week's recipe is an update on a classic: Blue Fuse 2020. Blue Fuse is one of the best recipes of all time, and LociOiling has updated it for modern use. Blue Fuse automates the process of shaking and wiggling while slowly increasing the clashing importance: a great tool for stabilizing your fold!

Player of the Week

Big thanks to jeff101 this week for always being helpful to new players in global chat, especially now as Education mode is helping students this semester! And thanks to all of our veteran folders who help newcomers learn to fold. You rock!

Today’s Master Folding Tips

Beginner: Having trouble getting the protein where you need it to go? Try turning the clashing importance to 0 to pull things easier without unintended consequences. Or use the Cut and Move technique!

Intermediate: Your eyes play tricks on you! Don't forget to keep moving your camera around to see the 3D shape of your fold. Try going into Sphere view and Stick view to get different perspectives on the shape of your protein as well!

Expert: Did you know that the orientation of donors and acceptors is important for forming good hydrogen bonds? Check out the cheat sheet below, courtesy of uihcv!

Want to learn more about the science of Foldit? Check out Foldit Education mode!

Until next time, happy folding!

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Newsletter September 11: Y'all Are Maaad Good at This Game

Hey folders!

Dev Josh here with your weekly Foldit update. And, just because I don't say this enough, thanks for playing everybody. You impress me every week with your creativity, persistence, and commitment to contributing to science, and I think I speak for all of the scientists when I say we really, really appreciate your efforts.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1884: Refinement Target R1056

Here's a full look at one of the best solutions for this refinement puzzle.

Puzzle 1885: Symmetric Trimer Design: H-Bond Networks

Puzzle 1886: Coronavirus Binder Design 17

Recipe of the Week

This week's recipe is Ma-a-a-ad good! Check out Maaa by Bruno Kestemont to "Mutate Authorized Amino Acids." Unlike the standard Mutate tool, which tries every amino acid possibility, with Bruno's Maaa, you can deny and allow specific amino acid mutations. This is great for preserving your orange hydrophobics or mutating explicitly for making hydrogen bonds.

Player of the Week

Shoutout to HuubR for being a big help in chat this week!

Today’s Master Folding Tips

Beginner: Having trouble with the tutorials? Check out this tutorial guide by S0ckrates! Or check the wiki for walkthroughs! Or ask questions in chat, there's lots of friendly folks happy to help you!

Intermediate: Having lots of candy cane colored hydrogen bonds is nice, but good packing is better. Rather than trying to make hydrogen bonds appear, focus on satisfying as many polar groups as you can and aligning the bond angles for strong connections. (This tip courtesy of uihcv, thanks!)

Expert: Sometimes the best way to learn is to teach. Take a look at your group's shares and try to evolve it by hand, consciously. Think about why you're making the changes you're making, and leave notes on what you did and why. Share it back with the original creator and talk to them about what you did to improve their design. You might learn a thing or two from the process!

Want more tips and news? Subscribe to our YouTube channel and click the bell icon so you get notified when our lab reports go live!

Until next time, happy folding!

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Newsletter September 18: Coming Up Roses

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1888: Symmetric Trimer Design: H-Bond Networks

Puzzle 1889: Coronavirus Anti-inflammatory Design 12

Recipe of the Week

This week's recipe is one of Rav3n_pl's GAB recipes, cleaned up by Bruno Kestemont. Try it out for some mid to late game improvements!

Player of the Week

A big Foldit welcome to Jumper2, one of our newest folders who has been great company in chat and a big help in providing feedback on the Discord. Jumper2 is one of the newest members of Gargleblasters. Thanks for folding with us!

Art of the Week

This week's art is titled "Bouquet of Roses" by BootsMcGraw. Not only is this four-helix design pretty, it's one of the top scoring solutions of puzzle 1888! Great job Boots! Want to fold with the famous cowboy of Foldit? Join the Contenders!

Today’s Master Folding Tips

Beginner: Are your loops too long? Most loops in the top Foldit designs are 5 residues or shorter! Bruno's Design Models is also a great way to get started with a design!

Intermediate: Challenge yourself to try something new every puzzle! Try a new recipe or a new strategy every time. Don't forget to write down what you did to collect notes on what worked and what didn't!

Expert: Want to shift an end residue to the other end? Here's a tip from Timo and Susume: 1) Use AA Edit to copy out your amino acid sequence; 2) Set your whole protein to be one long sheet; 3) Use tweak to flip the sheet once; 4) Use AA Edit again with your residue shifted to the other end to reapply your AA sequence how you want it. (Presumably, you also return your SS to how you want it!) Thanks Timo and Susume for the tip!

Don't forget to follow us on Twitter for the latest updates on your favorite protein-based game through your favorite bird-based social media platform!

Until next time, happy folding!

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Newsletter September 25: Raspberry Remix

Hey folders!

Dev Josh here with your weekly Foldit update. Got a Raspberry Pi and want to run Foldit on it? Check out this player's guide on our forums!

Solutions from This Week's Puzzles

Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1890: Revisiting Puzzle 136: Cell Adhesion

Puzzle 1891: Symmetric Trimer Design: H-bond Networks

Puzzle 1892: Coronavirus Binder Design: Round 18

Recipe of the Week

This week's recipe is the classic Deep Remix Worst by Timo van der Laan, or TvdL's DRemixW for short. This great late game recipe can help remix your design automatically, especially if you give it a few hours or even overnight.

Player of the Week

Shoutout to aqsw, one of the new folders for Go Science, for being so welcoming in the Foldit Discord! Glad to have you folding with us, aqsw!

Today’s Master Folding Tips

Beginner: Tired of wiggling all the time? Try running a recipe like this one!

Intermediate: Practice your hand-folding by challenging yourself to not run any recipes until late game!

Expert: You might know that the Blueprint tool adds torsional constraints, which is why you want to take them off during the late game. But did you know that those constraints are different than the ones the Blueprint starts in? Each Blueprint block has "adjusted" torsions so that things lock into place nicely when you're constructing a backbone from scratch. Then the torsional constraints help
bring things back into ideality the next time you wiggle. For example, if you made two ideal helices in Foldit and used an un-adjusted ideal AGBBA loop, the ideal helices would not align parallel to one another -- they would flare off at a skew angle. Usually we want the helices to be parallel to each other, but this requires some tiny adjustments to "perfect ideality".
For more on the Blueprint tool, check out this blog post!

Missed this week's Office Hours? Check the transcripts here! Don't forget to give us feedback on them! Did we answer all of your questions? Do you want Office Hours to be something different? Let us know!

Until next time, happy folding!

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Newsletter October 2: It's Fall Y'all

Hey folders!

Dev Josh here with your weekly Foldit update. Happy October! And Chag Sameach to all of our Jewish folders playing on this week of Sukkot.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1894: Symmetric Trimer Design: H-Bond Networks

Puzzle 1895: Coronavirus Anti-inflammatory Design 13

Recipe of the Week

Do you enjoy running TvdL's DRemixW but wish that it stopped turning your hydrophobics into hydrophilics? Try Susume's Orange Guard version! Just freeze your hydrophobics before you run it, and this DRemixW variant will only mutate those residues into other hydrophobics. Thanks Susume!

Player of the Week

A quick shout-out today to Jumper2, one of the newest members of Gargleblasters and a welcome addition to the Foldit family! Thanks for all of your great questions and feedback!

Art of the Week

This week's art was made by malphis. Cool stuff! Want to make your own Foldit art? Post your screenshots on the Foldit Discord! This month's theme is: Pumpkins!

Today’s Master Folding Tips

Beginner: Challenge yourself to get 9,000 points on all of the Beginner puzzles! Then 10,000, then 11,000! Ask for help in chat if you get stuck on how you can make improvements, and share screenshots with the camera button.

Intermediate: Want to get a better SASA score for binder puzzles like Coronavirus? Try bander recipes, like Blue Fuse or Quake. Thanks nspc for the tip!

Expert: Here's a handy cheat sheet for ideal loops in the Rama map, courtesy of uihcv! Notice that one of the loops (Helix-Helix; red green blue blue red) has the second (green) residue in an unsatisfactory region. Curious why that is? Check out last week's expert tip to find out!

Missed this month's Lab Report? Check it out here! And don't forget to come to next week's Office Hours with Dr. Scott Horowitz, on Friday Oct. 9 at 19:30 UTC (12:30pm PT; 3:30pm ET) in #veteran chat, or on the Foldit Discord!

Until next time, happy folding!

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Newsletter October 9: Making a Tri-Dent in Coronavirus

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1897: Symmetric Trimer Design: H-Bond Networks

Look at all these great sheets! Coloring in CPK.

Puzzle 1898: Coronavirus Binder Design: Round 19

Triple helix is still the best way to go, but how do you attach? Here are some top scoring examples! Coloring in ABEGO.

Recipe of the Week

Looking for something new to shake out your design draft in the early game? Try this recipe by Bruno Kestemont! A few mutates, some shakes and wiggles, you can't go wrong!

Player of the Week

A big thanks to JoannaH for folding with us since 2010! Joanna was the top scorer for Coronavirus Binder Design Round 19 and currently holds the top spot in this week's Anti-Inflammatory Design Round 14! Plus, she's just a great person to talk to. Say hi next time you see her in chat!

Art of the Week

This week's art comes to us from Formula350: "Poseidon's Trident". Nice one, Formula!

Today’s Master Folding Tips

Beginner: Did you know you can band the protein to empty space? Drag a band from the protein to any point in space to create a zero-length band ("ZLB"), also known as a spaceband. This band will try to hold that part of the protein exactly where you point it to in 3D space!

Intermediate: Having trouble with BUNS? Try hand-folding them into a better position in the mid-game, then freeze them where they are while the BUNS are resolved for your late game refinement.

Expert: Don't forget to update your recipes with these latest versions! HNetwork Probe 2.1 by spvincent, Design Models 2.3.3 by Bruno Kestemont, and Simulated Annealing 5.0 by KarenCH just came out this week!

Have a question about the science of Foldit? Ask it in our #science channel on Discord!

Until next time, happy folding!

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Newsletter October 16: Galaxie Breaks a New Record!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1900: Symmetric Trimer Design: H-Bond Networks

There were a lot of diverse solutions this week with really great networks (in my non-scientist opinion). Check out all these different structures!

Puzzle 1901: Coronavirus Anti-inflammatory Design 14

Recipe of the Week

Need some band utilities? Try band equalizer,
originally by truestone. This handy recipe can rapidly adjust band properties. Want all your bands of length 3.5 to be length 2.0? Done. Want every
band to be strength 10? You got it. Never manually adjust band properties again, this recipe does it all at once!

Player of the Week

A huge congratulations to Galaxie
for being the first player ever to earn 100,000 overall soloist points!! This is absolutely incredible dedication. Want to play on Galaxie's team? Join Anthropic Dreams!

Art of the Week

From biochemistry to biology, this week's art comes from Formula350! Keep crawling on!

Today’s Master Folding Tips

Beginner: Did you know there are a bunch of different options for viewing your protein? Try playing around with the View settings, you might find that different settings help you in the early, mid, and late game of a puzzle!

Intermediate:
Here's a few binding tips from nspc:
try to make a stable protein before binding to your target. Don't forget to pull it away again to make sure it's still stable after you optimize it! The protein needs to be stable on its own as well as when binded. Nspc's strategy is to detach, mutate, attach, mutate, and repeat. But JoannaH's strategy is to do most of her mutating detached, then try mutating as little as possible while attaching to the target.

Expert: Do you know your Koga & Koga rules for connecting sheets and helices together in short loops? Check out this wiki page for quick tips on what kind of chirality and parallelity each loop type prefers!

Have a tip, recipe, or artwork submission for the next newsletter? Ping @Josh on the Foldit Discord with your suggestions.

Until next time, happy folding!

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Newsletter October 23: Two helices, both alike in dignity...

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1903: Two-Sided Interface Design

Puzzle 1904: Coronavirus Binder Design 20

Recipe of the Week

An old recipe, but a fan-favorite. Make your helices curlier with the Helix Curler by Rav3n_pl!

Player of the Week

This week's spotlight goes to NeLikomSheet!
Although they've only been folding since March, they made it to the #3 spot on the latest Aflatoxin challenge. Great job!

Today’s Master Folding Tips

Beginner: Once you're in a group, you can load in other groupmates' solutions and improve them for points! This is one of the best ways of learning how to fold.

Intermediate: Remember "MALEK": methionine, alanine, leucine, glutamate, and lysine. These are the amino acids that love to be in helices!

Expert: Make sure you're familiar with all of the hotkeys Foldit has to offer so that you can fold at your fastest!

Until next time, happy folding!

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Newsletter October 30: Sliders and Spirals

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1907: MERS-CoV Binder Design

Puzzle 1905: Aflatoxin Challenge: Round 19 Loop Prediction

Art of the Week

This week's artwork comes from Formula350 and Ridick051!

Players of the Week

A huge thanks goes out this week to our volunteer contributors: LociOiling and NinjaGreg. Some of their improvements to the game will be rolling out this month and next, so if you see them in chat, give them thanks for volunteering their time to make Foldit better!

Today’s Master Folding Tips

Beginner: Do you use the Clashing Importance (CI) while wiggling, shaking, or mutating? Try lowering the CI to let the protein pack itself tighter, then raise it up again to let it relax!

Intermediate: Use the "Show bondable atoms" and "Show bondable hydrogens" visualization options to see what you can line up to form new bonds!

Expert: Wondering how to use the new devprev features? Use the new hbond sliders to change the priority of forming hydrogen bonds! The backbone hbond slider is for backbone-backbone hbonds only, while the sidechain slider is for any hbonds that involve sidechains, including to ligands and binder targets! Try raising the slider up to force bonds, then relaxing it down. Remember that you are scored at the sliders' default values: like CI, tweaking the slider might help you form a better shape, but it won't get you a better score directly. There are also new Lua functions to use these sliders, as well as hidden sliders for packing, pairwise, and density subscores! Check out the documentation here!

Have a safe and happy Halloween! And until next time, happy folding!

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Newsletter November 6: Folding Tetris

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1909: Symmetric Tetramer Design: H-Bond Networks

There were lots of cool tetramer designs this week! Here's some music to listen to while you fold your tetramers!

Puzzle 1910: MERS-CoV Binder Design: Round 2

Player of the Week

A big thanks to leejunil06 (aka cjddig) for working on a Korean translation of Foldit! Thanks so much for your volunteer efforts!

Today’s Master Folding Tips

Beginner: Having short loops and long helices is one of the easiest ways to rank up in the leaderboards! This helps you focus on the fundamentals of refining a fold.

Intermediate: Are you getting full points from the metrics bonuses? The best way you can contribute to science is to design a protein with full metrics bonuses, share it with scientists, then start over and repeat! Our scientists will really appreciate having multiple designs that meet all of our metric goals.

Expert: Wondering how to use the new sliders that everyone's talking about? Check out this wiki page for tips! Don't forget that there are new Lua functions for changing pairwise, packing, and density behavior too!

Have you figured out a good method for using the new sliders? Make a recipe and share it with everybody! You might be featured in next week's Recipe of the Week!

Until next time, happy folding!

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Newsletter November 13: Huge Update Coming Soon!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1912: Designable Linker: Coronavirus Spike Binder

Puzzle 1913: MERS-CoV Binder Design: Round 3

Recipe of the Week

Want to play around with the new sliders? Try my modification of Blue Fuse! This quick recipe performs some shakes and wiggles between modifying sliders of your choosing, like clashing, hydrogen bonding, packing, and hiding subscores. And if you're curious to get into writing your own recipes, try opening this one up and tweaking the values, it's a pretty simple recipe!

Player of the Week

A quick shoutout to Beany for being a friendly voice in chat! Beany is new to folding as of May, so if you see them online, be sure to give them a friendly Foldit welcome!

Updates from the Developers

This week we saw a lot of changes coming into the developer preview, or "devprev" of Foldit! Here's a quick breakdown of everything to look out for as this preview gets ready to be released!

Bands have new colors!

Rubber bands are now purple only when they are 3.5 Angstroms long (the default length for rubber bands and the best length for backbone-backbone bonds). At 2.0 Angstroms (the best length for sidechain hydrogen bonds and disulfide bridges), rubber bands are green. Otherwise, they're orange. Bands also change color slightly based on their strength so that you can easily tell bands of different strengths apart.

No recipes? No problem!

If your Cookbook is too empty, you now have a Cookbook Starter Pack! Run this pack to download a bunch of useful recipes! We also added a few new recipe functions, like Ideal SS and the ability to tell whether a band was made by a recipe or a human.

All the options!

The options menu received a huge overhaul! Not only is it prettier, but there are new settings for band preferences and sliders to adjust volume and font size! Even the hotkeys got an update: you can now bind recipes and the Rama Map to hotkeys!

Oh, we were holding it upside down

By popular demand, we have reversed the default camera zoom direction and switched the right mouse button and middle mouse button camera controls. You can change this back in the options menu if you prefer the old controls.

Unlimited talk and text

Text boxes now support text selection and undo/redo like modern text editors! The chat window has also been upgraded in a bunch of ways.

A full list of all of the new features is available here. We hope you enjoy this huge update!

Known Issues

If you discover a bug not on this list, please let us know!

*The notifications panel is not displaying properly
*The new importance sliders cannot be clicked to reset their value
*The puzzle name is not clickable
*Some options are not being saved properly

Want to try the developer preview of the latest updates and be a beta tester? In your Foldit files, open options.txt and change "update_group":"main" to "update_group":"devprev". Don't forget to let us know about any bugs you find! We always welcome feedback of any kind! Keep your eyes and ears out for more updates, something just as big might be coming soon... ;)

Until next time, happy folding!

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Newsletter November 20: A Breeze with DLPs

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1915: Designable Linker: Coronavirus Spike Binder

This week saw a return of DLPs, or Designable Linker Puzzles. In this puzzle, you need to design a protein that links two separate binder proteins. To help you get a better idea of what makes a good linker, I've arranged an entire gallery for you. This gallery ranges in scores from top-scoring (35,000+ points) all the way to the back of the leaderboards, in descending order. What patterns do you notice about high-scoring designs? How do they arrange their secondary structures, or make hydrogen bond networks, or use hydrophobics to hold their linker together?

Player of the Week

Lately we've been seeing a good hustle from Enzyme of the Gargleblasters, coming in second place for the last two DLPs and grabbing the #1 spot on MERS-Cov Binder Design Round 3. Say hi to Enzyme if you see them in chat!

Today’s Master Folding Tips

Beginner: Just finished the tutorial and not sure what to do? Try joining a group and evolving a solution! The Beginner puzzles are good practice, but if you really want to fold like a pro, check out what other people are making and try to make designs like theirs.

Intermediate: Don't be afraid to share what you have and try something totally different! You'll learn much faster by doing the early to mid game repeatedly instead of spending the whole week in the late game.

Expert: Want to earn favor with the scientists? Right now, we just need a *lot* of different designs that meet our metrics demands! Try challenging yourself to see how many unique designs you can share with us that all earn the full metrics bonuses.

Looking to learn more about Designable Linker Puzzles? Come to neilpg628's office hours tomorrow (11/21) at 10am PT / 18:00 GMT!

Until next time, happy folding!

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Newsletter November 27: Thanks!

Hey folders!

Dev Josh here with your weekly Foldit update. Happy Thanksgiving to those who celebrate it this week. We're thankful that all of you volunteer your time to contribute to scientific discovery!

This week we also made a big announcement: in the new year, we'll be rolling out a new website and switching to only Lua V2 recipes. So if you have GUI or Lua V1 recipes that you like, now is the time to port them over! Check out the news post for resources on how to do this conversion.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1918: Designable Linker: Coronavirus Spike Binder

Puzzle 1919: Rosetta Decoy 7

Player of the Week

Congratulations to ZeroLeak7 (aka Ridick051 in chat) for taking the #1 spot in Puzzle 1918! Catch them chatting up #global or posting memes in #veteran. Thanks ZeroLeak for being part of the Foldit family!

Today’s Master Folding Tips

Beginner: Try using the Blueprint tool for drafting your designs!

Intermediate: Sometimes Ideal SS is way too harsh for cleaning up helices, as it'll just completely warp everything out of place. Instead, one of my favorite ways for gently making helices is to band every residue in a helix to the residues 3 and 4 segments away from it. Because helices turn every 3.6 residues, this banding technique nudges them into the correct helical shape gradually and keeps them there. Jeff101's makehelix recipe can help you do this automatically, too!

Expert: Check out this preprint article! And then think about trying some more valines in your core ;)

Need a GUI recipe converted for you? Send an email to mail.fold.it@gmail.com with a link to the recipe you'd like converted!

Until next time, happy folding!

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Newsletter December 4: A Bit of a Bind

Hey folders!

Dev Josh here with your weekly Foldit update. This week we've noticed some performance issues with the game, and we appreciate your patience as we work on making improvements! Expect some fixes and new features coming soon!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1920: MERS-CoV Binder Design: Round 5

Puzzle 1921: Designable Linker: Coronavirus Spike Binder

Player of the Week

I'm delighted to welcome back Thunk to the Foldit community! Say hi to xem if you see xem in chat!

Today’s Master Folding Tips

Beginner: The automated tools are fun for getting points, but the overall shape is more important! Try comparing your designs to the proteins shared in these newsletters to understand what a good design looks like and how your protein's shape can be better.

Intermediate: Measure twice, cut once! Before you jump into a design, try planning it out. How many segments do you have to work with? What will your secondary structure be? Try sketching it out on paper first, then planning your secondary structure using the Blueprint tool before cutting and moving your pieces where you want them to be.

Expert: Try challenging yourself to a Foldit speedrun! Give yourself one hour to make a design, then share it with scientists and post a screenshot of your results to the Veteran chat to share it with the community!

Have a question for a developer? One of our lead developers, jflat06, will be holding Office Hours in #veteran chat on Sunday 12/6 at 1 PM PST (21:00 UTC). See you there!

Until next time, happy folding!

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Newsletter December 11: As Floppy as a Potato Pancake

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1923: MERS-CoV Binder Design: Round 6

Puzzle 1924: Designable Linker: Coronavirus Spike Binder

These designs seem okay, but watch out for loose links! I'm no scientist, but I've circled in red what I think might be problems for binding -- if the only connection to the target is a loose loop, the protein will just flop all over the place! Imagine giving all of these designs a vigorous shake: which ones do you think will hold their shape, and which will bend or snap?

Recipe of the Week

It's Hanukkah this week, so here's a recipe for making potato latkes! And while you're enjoying some good fried food, you can run ZeroLeak7's QuakeR with mutate for binders. L'chaim!

Player of the Week

Welcome back REDing! We're happy to have you folding with us again, and I'm sure Team China is happy to have you back as well. Good luck!

Today’s Master Folding Tips

Beginner: Not sure how to start a design? Check out this guide video by Susume!

Intermediate/Expert: Make sure your binders have good packing! Use lots of hydrophobics everywhere your binder might touch the target to ensure a good stick!

Missed this month's lab report? Check it out here!

Until next time, happy folding!

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Newsletter December 18: Snow Day!

Hey folders!

Dev Josh here with your weekly Foldit update. It's finally winter for Foldit, and you know what that means: time to make snowflakes! A new snowflake puzzle will be coming soon so you can make some symmetrical protein snowflakes. Be sure to click "Share with Scientists" to send us your creations! Afterward, the Foldit team will pick our favorites and feature them on the front page!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1926: MERS-CoV Binder Design: Round 7

Puzzle 1927: Designable Linker Puzzle: Coronavirus Spike Binder

Recipe of the Week

Looking for something sweet for the holidays? When I make sugar cookies, I do something like this but with an extra 1/4 cup of flour, 1 more egg, and twice as much butter (and maybe a little extra salt to taste). Whatever you decide to bake, don't forget to share pics with us on the Discord! And while you're selecting a cookie to make, try selecting bands with this utility recipe!

Player of the Week

This week's top folder is Mike Lewis of the Gargleblasters! Mike was the #1 Evolver on the last two Designable Linker puzzles, and had their work featured in the Design of the Month! Great job Mike!

Today’s Master Folding Tips

Beginner: Not sure what a good protein looks like? Check out the various galleries on the Foldit wiki! Experts are always posting their solutions for you to observe and learn from.

Intermediate: Having trouble fixing an unideal loop? Try temporarily re-assigning an adjacent helix/sheet segment to a loop so that a local wiggle can try different angles! Don't forget to freeze the first segment of each secondary structure on either side so that you're not wiggling everything.

Expert: This week Susume shared an interesting paper on pi stacking with tryptophan in the Foldit Discord #science channel. Check it out here!

Good luck with your snowflakes, and as always, thanks for your contributions to science!

Until next time, happy folding!

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Newsletter December 25: Merry Christmas!

Hey folders!

Dev Josh here with your weekly Foldit update. Merry Christmas to all who celebrate it! If, like me, you aren't Christian, then happy Friday!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1930: Designable Linker Puzzle: Coronavirus Spike Binder

Puzzle 1929: Two-sided Interface Design

Video of the Week

Check out Bruno Kestemont's guide to designing a linker! Bruno says: at the start, don't look at the score, only look at the structure, and try to satisfy all of the objectives. Then you can start with recipes, always making sure that your objectives are still okay. Bruno recommends running Quickfix or JET after drafting a design like this!

Bruno is one of our top expert folders! If you see him in chat, thank him for the guide!

Player of the Week

A warm Foldit welcome to maithra (aka kcmolnar) who has been asking wonderful questions in chat! Maithra just started two months ago, and already they've taken the top 25 in puzzle 1929! Go maithra!

Art of the Week

Christmas Tree by Formula350

Today’s Master Folding Tips

Check out the "How to Foldit" blog series starting up this week! There's tons of stuff for newbs and pros alike, so be sure to give it a read!

Have happy and safe holidays! And don't forget to try out the Snowflake Challenge!

Until next time, happy folding!

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Newsletter January 8: From 2020 to 2021

Hey folders!

Dev Josh here with a special weekly Foldit update. Last week we were out celebrating the new year so that today we could bring you our 2020 year in review with a look-ahead to what you can expect in 2021! A lot happened this year for Foldit! Despite the many, many things terrible with 2020, Foldit saw some great improvements this year, such as:

  • Our first full year of Lab Reports
  • A bunch of new features, UI improvements, and general quality-of-life changes
  • TONS of bugfixes

Plus, all of this news!

January

February

March

April

May

June

July

August

September

  • Foldit Educational Mode is announced to the scientific community with a Publication

October

November

December

2021

What great things can we expect in the upcoming year? Of course, I can't make any promises, as all of this is subject to change, but here are some things the Foldit team is thinking about:

  • A new website with a ton of improvements
  • A new practice mode for beginner to intermediate folders
  • Some major changes might be coming to the tutorials
  • We hear your complaints about the UI and we're thinking about how we can make the interface better
  • Even more bug fixes!!
  • We're investigating some major backend code improvements to make development smoother and performance better

As always, thanks so much for being a part of this community and contributing to science. Here's to a great new year!

Until next time, happy folding!

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Newsletter January 15: Back to School

Hey folders!

Dev Josh here with your weekly Foldit update. Keep an eye out for the Snowflake Challenge results next week!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1938: Symmetric Tetramer Design: H-Bond Networks

Puzzle 1940: Revisiting Puzzle: Rosetta Decoy 14

Player of the Week

It's not often that someone gets Player of the Week twice, but leejunil06 (aka cjddig) has earned it! If you're interested in Foldit's Educational mode, they've made a bunch of tutorial videos for it!, Especially if you're a student who's been struggling with primary structure, these videos are for you!

Today’s Master Folding Tips

I can tell if you're reading this that you want to learn more about how to get good at Foldit. Check out our latest blog post series, "How to Foldit"! Part 3 of 10 has just been released, with a new part coming out every week. This week we're looking at your tools of the trade. Whether you're a noob or pro, there's something to learn in this post!

Got a question? Bring it to the next Office Hours with Dr. horowsah on Sunday the 17th at 17:00 GMT!

Until next time, happy folding!

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Newsletter January 22: WE FIXED BANDS

Hey folders!

Dev Josh here with your weekly Foldit update. Great news! We were able to make some huge performance increases, including speeding up banding by like 4000%. We're continuing to look at performance issues and make Foldit smooth as silk. Enjoy!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1941: Symmetric Tetramer Design: H-Bond Networks

Puzzle 1942: Designable Linker: Coronavirus Spike Binder

Recipe of the Week

Now that we're in the dead of winter, here's a hearty beef stew recipe to keep you warm. And while you're away enjoying that stew, let ZeroLeak7's AFK3.5Fast do your folding for you! That's a delicious win-win.

Player of the Week

A big congratulations to ichwilldiesennamen! Despite only starting in March, this competitive folder quickly rose through the ranks to become the global #1 soloist! Herzliche Glückwünsche!

Today’s Master Folding Tips

Check out Part 4 of How to Foldit! This week we're covering tools for refinement. If you were around in February when I was streaming, you know how badly I needed these tools. This post will help you learn how to use them better than I ever could.

Don't forget to subscribe to our YouTube channel so you can stay up-to-date on the latest Lab Reports and guide videos!

Until next time, happy folding!

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Newsletter January 29: Stay Safe

Hey folders,

Dev Josh here with your weekly Foldit update. I'm writing this from upstate New York where the wind is blowing hard and the snow is coming down and it's freezing outside. I'm thinking about our global situation and our wonderful Foldit player Mike Cassidy who has been ill with COVID-19. I hope he, and everyone else affected by this awful disease, are doing as best as they can be. Stay safe, everyone. We are facing difficult times, but with persistence and community we will survive this crisis.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1944: Symmetric Tetramer Design: H-Bond Networks

Puzzle 1945: Designable Linker: Coronavirus Spike Binder

Recipes of the Week

Need something different to fold to? Here are a few recipes for disaster.

Today’s Master Folding Tips

Check out part 5 of How to Foldit. In this part, I talk about all of the visualization options available to you and why you'd want to use each of them.

Have a good design? Don't forget to click the Share with Scientists button so our scientists pay extra attention to it.

Until next time, happy folding.

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Newsletter February 5: Tetramers and Quartets

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1947: Symmetric Tetramer Design: H-Bond Networks

Puzzle 1948: Designable Linker: Coronavirus Spike Binder

Art of the Week

“Harp Quartett” by HuubR

Today’s Master Folding Tips

Check out How to Foldit, Part 6: Mastering Objectives. In this installment of our weekly series, I describe all of the Objectives you might encounter and what to do about them. But you experts might notice I’ve left the new one out: the Contact Molecular Surface metric. Let’s talk about it on the Discord! Share your insights about the Contact MS metric and tag @Josh so we can talk about the best strategies for solving that metric.

Have a question? Ask on our forums or in the #global chat! Players and developers alike are always happy to chat!

Until next time, happy folding!

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Newsletter February 12: Starting the Lunar New Year with a BAM!

Hey folders!

Dev Josh here with your weekly Foldit update. Happy Lunar New Year!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1950: Two-sided Interface Design

Puzzle 1951: Designable Linker: Coronavirus Spike Binder

Puzzle 1952: BAM Complex with Electron Density

Recipe of the Week

To celebrate the new year, try these steamed bao buns! And then try Kuwaga’s Repeat Settle, converted to Lua by WBarme1234. Delicious!

Today’s Master Folding Tips

Check out Part 7 of How to Foldit. This week, I take you through the jargon you might see when talking with a veteran folder, as well as some details on every amino acid in Foldit.

Have a recipe to recommend? Email us at mail.fold.it@gmail.com with a link to your recipe so we can share it in the next newsletter!

Until next time, happy folding!

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Newsletter February 19:

Newsletter February 19: You won't believe how this binder got a high score!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1953: Influenza HA Binder Design

Puzzle 1954: Symmetric Tetramer Design: H-bond Networks

Puzzle 1955: Scorpion Toxin

Recipe of the Week

This week’s recipe is Optimizer by cjddig. This is their first recipe, so be sure to rate it and give them feedback on Discord! And don’t forget to check out their Foldit streams at Twitch!

Today’s Master Folding Tips

Check out Part 8 of How to Foldit! In this part, I describe a TON of useful recipes as well as when, why, and how to use them!

Looking for a flatter puzzle, maybe with some RNA instead of proteins? Check out our sister game, Eterna!

Until next time, happy folding!

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Newsletter February 26: Let's Start Over...

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1956: Influenza HA Binder Design: Round 2

Puzzle 1957: Designable Linker: Coronavirus Spike Binder

Puzzle 1958: BAM Complex with Electron Density

Recipe of the Week

Want to start your puzzle fresh? Try tlaloc’s Make Denovo to pull your whole protein apart into an extended chain. Just be aware that this is a V1 recipe and won’t be supported soon, so if you like it, check out this post for information on how to convert it to V2.

Player of the Week

This week’s Player of the Week is Drum, aka drumpeter, aka disturbedxxx666. Drum has been folding with us since 2012, and their presence is always a pleasure in chat! Thanks for being a dedicated folder, Drum!

Today’s Master Folding Tips

We’re almost at the end of the How to Foldit series! Check out Part 9 for a look at subscores and some general strategy tips.

Want to see a player or recipe highlighted in the next newsletter? Send us an email at mail.fold.it@gmail.com!

Until next time, happy folding!

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Newsletter March 5: The Last Trimer Will Shock You!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1960: Symmetric Trimer Design: H-Bond Networks

I am always surprised by the ingenuity of Foldit players... Great job everybody!

Puzzle 1961: Beta-Neurotoxin

Recipe of the Week

Not sure where to start on your design? Try SSPred by BitSpawn to help you figure out your secondary structures!

Player of the Week

This week’s spotlight goes to NeedMoreCoffee, who’s been folding with us since 2008! Thanks for sticking with it! I too could use more coffee...

Today’s Master Folding Tips

Like chess, Foldit is a slow, thoughtful game. Visualize the design you want, then work methodically to make it happen. Not sure what a good design looks like? Check out my gallery of folds, or check the wiki for previous puzzle results!

Reading this on the forums? Sign up for the mailing list here so you can stay up-to-date when these newsletters are first released!

Until next time, happy folding!

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Newsletter March 12: AI ML YYDS FTW

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1962: Influenza HA Binder Design

Puzzle 1963: Two-sided Interface Design

Puzzle 1965: Insulin Mutant

Recipe of the Week

Are you a fan of machine learning? Try AI Learns nCoV by Vincero. This recipe evolves the work of zo3xiaJonWeinberg and Grom to make an optimizing recipe that even optimizes itself!

Player of the Week

A big thanks to the students from the University of Science and Technology Beijing for folding with us! We are delighted to see you all learning with us in chat. Xie xie!

News from the Baker Lab

The scientists at the Baker Lab have cooked up a new way to calculate BUNS! Check out Susume’s summary here.

Today’s Master Folding Tips

Check out the tenth and final part of How to Foldit, out now. In this last installment, I describe how you can start thinking about Foldit in the way the scientists do, and I review some of the ways scientists think about protein designs.

Did you enjoy the How to Foldit series? Want more posts like that? Send us an email at mail.fold.it@gmail.com and tell us what you’d like us to write about next!

Until next time, happy folding!

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Newsletter March 19: A New Kind of Competition!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1964: Unsolved Huge Cryo-EM Density: Beet Virus

Puzzle 1967: Symmetric Trimer Design: H-bond Networks

Today’s Master Folding Tips

Want to write a recipe that cares about hydrogen bonds? Check out the new HBonds Lua function to see all of the information now available to you about your protein’s hydrogen bonding!

Upcoming Updates

Here are some updates to look forward to this week:

General

  • Updated the main menu and loading screens
  • The left/right arrow keys can now be used with the Segment Info panel to cycle between segment information in the Selection Interface
  • Added font support for Korean, Chinese, Japanese, Hebrew, Latin, and Cyrillic alphabets
  • Added Portuguese translation courtesy of Foldit player socramdm

Bug Fixes

  • Fixed a bug where deleting text in a note would sometimes not save
  • Fixed various bugs related to profanity filters

Special Competition!

In order to advance our scientific discovery, Foldit is holding a special competition for influenza hemagglutinin binder designs! How do you compete? The winner will be the soloist player who submits the most solutions with scores greater than 10,000 points. Every solution needs to be from a fresh restart (from scratch) and evolved solutions won’t count. And note, you need to use the Upload for Scientist button to submit your solutions. Bkoep gives some background on why we’re holding this competition in his blog post.

If you like playing Foldit to contribute to science, participating in this competition is the best way to do so right now!

Good luck, and until next time, happy folding!

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Newsletter March 26: Enter the Dojo!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1969: Symmetric Trimer Design: H-bond Networks

Puzzle 1970: TCR Binding Protein

Upcoming Updates

I’m very excited to announce a NEW GAME MODE coming soon! Dojo Mode is a brand new way to play Foldit and practice your folding skills. Check out this post for more information on what Dojo mode is.

Want to try out Dojo mode for yourself right now? Dojo mode is currently live in Foldit’s developer preview, or “devprev”, release. Here’s how to join devprev to see the latest updates.

Until next time, happy folding!

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Newsletter April 2: No Fools Here

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1971: Symmetric Trimer Design: H-Bond Networks

Upcoming Updates

Here’s a sneak peak at what patches are coming in the near future:

  • Bug fixes to Dojo mode
  • Bug fixes to the Reaction Design tutorial puzzle
  • Bug fixes for Objectives

As always, thanks to our devprev users for help testing out new Foldit features!

Player of the Week

Congratulations to fiendish_ghoul for taking the #1 spot on Puzzle 1972! Want to get better at ED? Check out the wiki for tips and tutorial videos!

Today’s Master Folding Tips

Beginner: Chat is your best resource! Say hi to folks when you go online.

Intermediate: Skip the late game and focus on your early-to-mid game hand-folding. If you don’t like how your design looks when you open up your cookbook, recipes won’t make it much better.

Expert: Instead of thinking of each amino acid as hydrophobic or hydrophilic, think about them on an atom-by-atom level! Carbons are non-polar and hydrophobic, but oxygens and nitrogens are polar. Use the carbons for hydrophobic packing, but make sure every O and N is bonded to avoid BUNS. Roll up your sleeves, making a great design requires getting into the gritty atomic details!

Missed this month’s Lab Report? Check it out here!

Until next time, happy folding!

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Newsletter April 9: Are you an early bird?

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1973: Tie2 Binder Design: Round 1

Designs by: NinjaGreg, sgeldhof, silent gene, and WakeOwl

Puzzle 1974: Symmetric Trimer Design: H-Bond Networks

Designs by BootsMcGraw, argyrw, fiendish_ghoul, Bruno Kestemont, and silent gene

Recipe of the Week

Now that it’s April, the worms are coming out! And check out this worm by ichwilldiesennamen. It’ll wiggle, mutate, and shake its way along your protein to improve your score without hurting your Objective bonuses.

Leaderboard Highlights

Let’s take a quick look at the tops of our leaderboards!

#1 on Puzzle 1973: toshiue

#1 on Puzzle 1974: BootsMcGraw

#1 Evolver: mirp

#1 Soloist: ichwilldiesennamen

Today’s Master Folding Tips

Did you know you can view old puzzle results here? Browse Foldit’s history to see what a good solution looks like!

Are you a recipe writer and wish there was more information from the Objectives? Hop onto our Discord and message @Josh with the Objective you’d like more information about. We’re looking into adding more Lua functions to tell you everything the Objectives know about your protein!

Until next time, happy folding!

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Newsletter April 16: How to Make a Triple Helix in Under 6 Minut

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1976: Influenza HA Binder Design: Round 5

Puzzle 1977: Symmetric Tetramer Design: H-bond Networks

Puzzle 1978: Designer Protein Top7

Player of the Week

This week’s highlight is robgee! Rob folds for Anthropic Dreams and has been playing since 2013! But robgee isn’t just any folding veteran, they’re also helpful to new players in #global chat. Say hi next time you see them in chat!

Upcoming Updates

Here are some improvements you can look forward to in the next devprev release:

  • Added new Dojo levels
  • Updated some Dojo levels for difficulty balance
  • Dojo mode now includes a Reset Puzzle button (but any Stamina spent will remain spent)
  • Dojo mode now includes a "Skip Level" button to give up on the current level
  • Not sure what Dojo mode is? Check it out in devprev!

Today’s Master Folding Tips

Check out this guide by nspc on how to create a triple helix in less than 6 minutes! They use this recipe to sketch out their helices.

Don’t forget to check out the next Office Hour with our website developer and systems admin jflat06 this Sunday (Apr 18) at 1pm Pacific Time! Can’t make it? Send in your question to mail.fold.it@gmail.com!

Until next time, happy folding!

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Newsletter April 23: Don't Miss This Talk by Dr. David Baker!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1979: TGF Receptor Binder Design

Puzzle 1980: Symmetric Trimer Design: H-Bond Networks

Puzzle 1981: Halorhodopsin

Recipe of the Week

Time to up your remix game with spvincent’s latest Loop Remix 11! This mid/late game remixer is much simpler and best for idealizing your loops in design puzzles. The details of how to use this recipe and all of its options are outlined by spvincent on the recipe page.

In Case You Missed It

David Baker, head of Foldit’s primary lab at the University of Washington, will be giving a lecture on “The Coming of Age of Denovo Protein Design” this Tuesday, April 27 at 4pm BST. The talk is free on Zoom, and more details can be found here. Thanks Susume for sharing this news on our forum!

Today’s Master Folding Tips

When using Blueprint, the residues are indexed as 1, 2, 3... To find a residue’s index, press Tab while hovering over a residue. This also shows more detailed information like what amino acid it is and a breakdown of how it’s scoring and why.

Reading this newsletter on the forums? Click here to get them sent straight to your email as soon as they go out!

Until next time, happy folding!

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Newsletter April 30: It’s Gonna Be May!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1983: Designable Linker: Coronavirus Spike Binder

Puzzle 1984: TNK1 with Density

In Case You Missed It

What’s scientifically valuable about symmetric designs? Find out in this forum thread with discussions by our in-house scientist bkoep!

Missed last week’s talk on “The coming of age of de novo protein design” by Dr. David Baker? Watch the recording here!

Today’s Master Folding Tips

Mutate can often put serine and threonine in your core when you really need hydrophobics.

Here are some mutate recipes to help with that: Maaa, Local Mutate, Mutate No Wiggle.

Foldit’s Turning 13!

Foldit’s 13th birthday is coming up on May 8th! Have you told your friends about Foldit? If this newsletter has 100 signups by May 8th, I’ll share some pictures of my cats as thanks!

Until next time, happy folding!

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Newsletter May 7: Happy 13th Birthday, Foldit!

Hey folders!

Dev Josh here with your weekly Foldit update.

Tomorrow is Foldit’s 13th birthday! We’re celebrating with a special science chat with the whole dev team! Check out the details here.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1985: TGF Receptor Binder Design

Puzzle 1986: Biotin Ligand Binder Design

Recipe of the Week

What’s a birthday party without ice cream cake? Of course, the best way to make ice cream cake is to Freeze All Sheets. And now you can, easy, thanks to srssmith92!

Today’s Master Folding Tips

Having trouble with your loops? Here’s a thread from the past if you want to get into some of the nitty-gritty, but some of the takeaways are: use freeze or cutpoints to isolate your loop, mutate everything to glycine (the one with no sidechain at all), and use the Rama map by finding those sidechains and dragging them into a colored region. Still having trouble? Post a screenshot to our Discord to get some help!

Don’t forget! If this newsletter has 100 signups by Foldit's birthday tomorrow, I’ll share some pictures of my cats as thanks!

Until next time, happy folding!

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Newsletter May 14: Eid Mubarak!

Hey folders!

Dev Josh here with your weekly Foldit update. Happy Eid al-Fitr to all who celebrate!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1988: Tie2 Binder Design

Puzzle 1989: Symmetric Tetramer Design: H-Bond Networks

Puzzle 1990: TNK1 with Density

Player of the Week

Congratulations to Bruno Kestemont for finally (after 9 years!) joining his own list of “Gold Players” who have achieved a worldwide #1 soloist rank!

Today’s Master Folding Tips

Forming good hbond networks is really important for a binder design. Good thing the wiki has tips and tricks!

Need some company while you fold? Take my cats!

Until next time, happy folding!

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Newsletter May 21: A Change of Seasons

Hey folders!

Dev Josh here with your weekly Foldit update. The seasons are a-changin’! It’s getting to be summer here in the U.S., and with it will come a host of new updates for Foldit. Dojo mode will be going live soon, so if you haven’t had a chance to check out the preview, you’ll get to play it shortly! We’re also hard at work on the new website, polishing up some front-end stuff so it’s nice and pretty when we release it.

Solutions from This Week's Puzzles

Want to have your name displayed with your solutions? Add your name to our opt-in form!

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1991: TGF Receptor Binder Design

Puzzle 1992: Symmetric D2 Tetramer Design: H-Bond Networks

Puzzle 1993: Thioredoxin

Today’s Master Folding Tips

The chat is one of your most valuable tools! Talk about your fold when you get stuck, add a screenshot, and you might just help yourself and others figure out your folds better!

Have a question about Foldit? Send it in to mail.fold.it@gmail.com and it might get answered in the next newsletter!

Until next time, happy folding!

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Newsletter May 28: Wiggling Spaghetti? Use Your Noodle!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1994: Influenza HA Binder Design

Puzzle 1995: Symmetric Trimer Design: H-Bond Networks

Other Citizen Science Games You Might Like

If you like Foldit, you might enjoy these other citizen science games too!

Eterna is a 2D puzzle about RNA. Imagine if Foldit was 2D, your only tool was Mutate, and there were only 4 choices. Sound easy? It’s not! Dive into the world of Eterna now to help India design mRNAs against B.1.617!

Do you prefer to chill out and color stuff in using your spatial reasoning skills? Check out Mozak and Eyewire, where you can help scientists map neurons in 3D space and better understand our brains!

Today’s Master Folding Tips

When you feel like you’re just moving spaghetti around, take a moment to pause and set a goal for yourself. Maybe you want your helices to look more straight, or your sheets to line up better. Set subgoals to work toward instead of vaguely wiggling toward a higher score. More often than not, you need to ignore your score for a while until your protein looks ready for polish!

Want to put your skills to the test? Try the new Dojo mode, out now! We’re still hammering the bugs out of this new game mode, so if you run into any issues, please report them here!

Until next time, happy folding!

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Newsletter June 4: P2K!

Hey folders!

Dev Josh here with your weekly Foldit update. Wow, can you believe we’ve launched 2000 puzzles? Incredible! Thank you for all of your help! With each puzzle, we step closer to understanding protein design and prediction, advancing our understanding of the world and what we can do with proteins. Here’s to 2000 more!

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1996: Unsolved Astrovirus Capsid

Puzzle 1997: TGF Receptor Binder Design

Puzzle 1998: Symmetric D2 Tetramer Design: Limited Interface

Upcoming Updates

Here’s what the devs have been working on lately:

  • Polishing improvements to the new website
  • Bug fixes to “Hello Blueprint”
  • New Lua functions
  • Updates to Education Mode
  • Code improvements for our puzzle creation process

And a special thanks to our volunteer contributors for helping with these updates!

Today’s Master Folding Tips

In case you missed it, check this thread for everything you need to know about how to play Foldit!

And don’t forget to subscribe to our YouTube channel so you get notified when there’s a new Lab Report!

Until next time, happy folding!

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Newsletter June 11: Soon with Even More Bits!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1999: Tie2 Binder Design

Puzzle 2000: Symmetric D2 Tetramer Design: Limited Interface

Upcoming Updates

What have the developers been working on recently? Here are some of our projects in the works:

  • A 64-bit version of Foldit for Windows
  • New puzzles for Educational Mode
  • Making recipes even easier to search, share, and download on the new website
  • Speeding up the Dojo server (turns out we forgot to feed the ferrets!)

Today’s Master Folding Tips

Have you seen Foldit through the eyes of a scientist? Check out this three part video series! Part 1, Part 2, Part 3.

Not in a group yet? Check out the Foldit groups to join one today!

Until next time, happy folding!

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Newsletter June 18: Not Many Problems, Just a Lot of Solutions

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 2001: Cytochrome

Puzzle 2002: TGF Receptor Binder Design

Puzzle 2003: Symmetric D2 Tetramer Design: Limited Interface

Puzzle 2004: Integrase

Player of the Week

Congratulations to sallallami, who joined us only a few weeks ago and has already risen through the ranks, taking the #1 spot on puzzle 2001!

Today’s Master Folding Tips

You can use Remix to fix non-ideal loops! Find out how in this video by LociOiling!

Want to use a recipe but don’t understand it? Tell us about it at mail.fold.it@gmail.com and we’ll break it down in a newsletter!

Until next time, happy folding!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons