Newsletter July 24: A Good Week for Go Science

Hey folders!

Dev Josh here with your weekly Foldit update. Congratulations to Go Science! for being the top of all three puzzles this week! Go Science has been an open and active group since 2010. One of the best ways to learn and improve in Foldit is to join a group.

If Go Science isn't your style, try the hopeful and determined Anthropic Dreams, the fun and light Gargleblasters, or the dedicated Contenders

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1863: Refinement R1043

I've heard this puzzle was crashing pretty frequently. Thanks for your patience everyone, the devs are hard at work trying to fix these issues!

Puzzle 1864: Symmetric Trimer Design: Limited Interface

To master this puzzle, you needed to limit how big your binding interface was. Notice how the top scores rotated their helical bundles to limit their attachments!

Puzzle 1865: Coronavirus Anti-inflammatory Design 8

Bkoep said there were 15 unsolvable BUNS, but some of the top solutions got them down to 11! Great job on satisfying those BUNS everyone, keep it up!

Want to know more about why we're designing binders from scratch? Check out this forum thread for details on why we're not just using the ACE2 receptor design.

Recipe of the Week

This week's recipe is new but with great potential:
mwm64's UnBun is designed to help you reduce BUNS. This recipe only works on puzzles with the BUNS objective, and I haven't personally tried it out much, but I've heard a few folks are trying it. Plus, if you're looking to get involved with recipe evolving, this simple recipe could be a good way to get some practice with Lua. Given how important the BUNS objective is, we're going to need more recipes like this! So thanks mwm64 for making the first de-BUN-ifier!

Player of the Week

A quick shout-out this week to malphis, a friendly newcomer who joined a couple of months ago and has been really active in chat. Malphis has also been super helpful submitting bug reports to help the devs track down issues. Thanks!

Art of the Week

Looking for some more protein beauty? Check out this beautiful proteins blog! It's got a ton of real proteins that are naturally amazingly beautiful.

Today’s Master Folding Tips

Beginner: Before trying to wiggle your designed protein into the perfect shape, give it a mutate first! This will help the protein pack together better and give you a cleaner structure to work with. You can also mutate by hand: for example, although all of your amino acids start as isoleucine, it's actually better to set your loops to asparagine to start with.

Intermediate: Have you learned how to use the Rama map yet? We're working on a few new guides that should help make it easier to learn, but in the meantime Susume has two guides on how to use the Rama map to fix un-ideal loops and even copy a loop

Expert: Are you planning your design before you make it? Before you start drafting, spend a few minutes thinking about what your design will look like. How long will each helix and sheet be? Will you try to make pi stacks? What part of the protein will bind at the interface, and how will that give it shape complementarity? Once you're ready, use Loci's AA Edit and SS Edit to enter your design and give it a quick early/midgame rinse. Then hand it off to a novice member of your group to evolve and try another design!

Have a tip to share with the community? Reply with your wisdom, or post on our Forums!

Until next time, happy folding!

( Posted by  agcohn821 98 1189  |  Wed, 07/29/2020 - 18:53  |  0 comments )
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons