puzzle picture
1864: Symmetric Trimer Design: Limited Interface
Status: Closed

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RankGroupScorePoints
1Go Science19,049100
2Anthropic Dreams18,82473
3Gargleblasters18,65452
4Void Crushers18,56536
5Beta Folders18,56324
6Contenders18,28716
7L'Alliance Francophone18,15410
8Hold My Beer17,9846
9Marvin's bunch17,2904
10BOINC@Poland16,7012
11SETI.Germany15,9551
12Russian team15,8821
13Italiani Al Lavoro11,3631
14Trinity Biology10,7161
15Mojo Risin'2,1731
16Team Canada01
17Foldit Staff01


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Comments

bkoep's picture
User offline. Last seen 14 hours 26 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 72 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

HuubR's picture
User offline. Last seen 16 hours 50 min ago. Offline
Joined: 04/13/2020
Groups: Gargleblasters
Complex core: (no?) limits

The last sentence of the Description ("no limits on the Complex Core", "H-bond Networks") confuses me. It seems to contradict the first part of the description: "no H-Bond Network objective, but there is "Core Limit: Complex" objective".

Was the last sentence unintentionally copied from the previous Symmetry puzzles, or am I missing the point here?

agcohn821's picture
User offline. Last seen 11 hours 40 min ago. Offline
Joined: 11/05/2019
Groups: Foldit Staff
Question

Hi HuubR--I have passed your question along to the team. Thank you!

bkoep's picture
User offline. Last seen 14 hours 26 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Good catch!

The last sentence was a mistake that was shamelessly copied from previous puzzles. I've updated the puzzle description.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons