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1864: Symmetric Trimer Design: Limited Interface
Status: Closed


1Go Science19,049100
2Anthropic Dreams18,82473
4Void Crushers18,56536
5Beta Folders18,56324
7L'Alliance Francophone18,15410
8Hold My Beer17,9846
9Marvin's bunch17,2904
12Russian team15,8821
13Italiani Al Lavoro11,3631
14Trinity Biology10,7161
15Mojo Risin'2,1731
16Team Canada01
17Foldit Staff01

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bkoep's picture
User offline. Last seen 14 hours 26 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 72 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

HuubR's picture
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Joined: 04/13/2020
Groups: Gargleblasters
Complex core: (no?) limits

The last sentence of the Description ("no limits on the Complex Core", "H-bond Networks") confuses me. It seems to contradict the first part of the description: "no H-Bond Network objective, but there is "Core Limit: Complex" objective".

Was the last sentence unintentionally copied from the previous Symmetry puzzles, or am I missing the point here?

agcohn821's picture
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Groups: Foldit Staff

Hi HuubR--I have passed your question along to the team. Thank you!

bkoep's picture
User offline. Last seen 14 hours 26 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Good catch!

The last sentence was a mistake that was shamelessly copied from previous puzzles. I've updated the puzzle description.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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