1864: Symmetric Trimer Design: Limited Interface
|Name:||1864: Symmetric Trimer Design: Limited Interface|
|Expired:||07/22/2020 - 23:00|
|Description:||Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle has no H-Bond Network objective, but there is "Core Limit: Complex" objective meant to limit the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds.
|Categories:||Design, Overall, Symmetry|
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