puzzle picture
1861: Symmetric Trimer Design: Buried Unsats
Status: Closed

Summary

Name: 1861: Symmetric Trimer Design: Buried Unsats
Status: Closed
Created: 07/08/2020
Points: 100
Expired: 07/15/2020 - 23:00
Difficulty: Intermediate
Description: Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Categories: Design, Overall, Symmetry

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2Go Science18,12774
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5Void Crushers17,17727

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Comments

bkoep's picture
User offline. Last seen 2 hours 22 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +1700 +1600)
Ensures that at least 17 16 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 3 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

spvincent's picture
User offline. Last seen 30 min 55 sec ago. Offline
Joined: 12/07/2007
Groups: Contenders
It seems that the maximum

It seems that the maximum Core Existence bonus attainable is 1600.

bkoep's picture
User offline. Last seen 2 hours 22 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
You're right!

Good catch, I just edited the Objectives comment.

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