1853: Symmetric Trimer Design: Buried Unsats
|Name:||1853: Symmetric Trimer Design: Buried Unsats|
|Expired:||06/25/2020 - 23:00|
|Description:||Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, which penalizes buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.|
|Categories:||Design, Overall, Symmetry|
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