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Beginner Puzzle (<150): Coronavirus
Status: Active

Summary

Name: Beginner Puzzle (<150): Coronavirus
Status: Active
Created: 06/09/2020
Points: 100
Expires: 07/21/2020 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

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- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
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Categories: Beginner

Top Groups

RankGroupScorePoints
1Go Science13,409
2Hold My Beer13,335
3Chem Eng Thermo13,189
4Gargleblasters13,135
5Russian team13,115

Top Soloists

RankPlayerGroupScorePoints
1SuperEnzyme 171 350  13,565
2pangaena 171 73  13,510
3Jakki 171 1167  13,509
4JoshNZ666 171 1009  13,473
5gian667 171 543  13,464


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons