puzzle picture
1847: Foldit Player Design with Electron Density
Status: Closed

Summary

Name: 1847: Foldit Player Design with Electron Density
Status: Closed
Created: 06/04/2020
Points: 100
Expired: 06/11/2020 - 23:00
Difficulty: Novice
Description: This puzzle features a protein designed by fiendish_ghoul in Puzzle 1321! We recently solved the crystal structure of this protein, and here we are providing players with the refined electron density map at a resolution of 1.83 A. The crystal's electron density shows that this protein folds up exactly as fiendish_ghoul designed it, with RMSD of 1.1 A among C-alpha atoms! We want to give Foldit players a chance to see this electron density data and fold up the protein to fit the map.

This puzzle also features the new "Radius" setting in the Electron Density panel, which allows you to focus on smaller map regions by hiding peripheral density. For this feature, we recommend turning off "Fixed camera pivot" in your General Options, so that you can easily move the focus point around the density map.

Sequence:
EEVVVEIRIRVQREEKVRRLIKRILEEVKRESNSVEVHVETRKRNGEVEVHVRIRHDDKETIERLVERILREIKKLDKNSEVEVRTTTKR
Categories: Electron Density, Overall, Prediction

Top Groups

RankGroupScorePoints
1Team India17,004100
2Gargleblasters17,00271
3Go Science16,98449
4Anthropic Dreams16,97733
5Beta Folders16,96522

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Comments

alcor29's picture
User offline. Last seen 10 hours 17 min ago. Offline
Joined: 11/16/2012
Scoreboards not working

Scoreboards not working

alcor29's picture
User offline. Last seen 10 hours 17 min ago. Offline
Joined: 11/16/2012
on feedback too
alcor29's picture
User offline. Last seen 10 hours 17 min ago. Offline
Joined: 11/16/2012
web site

Also, web site seems to be taking a very long time to update. If at all.

alcor29's picture
User offline. Last seen 10 hours 17 min ago. Offline
Joined: 11/16/2012
nvm just upddated

web site just updated

Joined: 03/22/2020
Groups: None
Scoreboard

Scoreboard doesn't work

LociOiling's picture
User offline. Last seen 1 hour 43 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
scoreboards should be working now...

The Foldit team gave something a gentle nudge, and now we have scores.

bkoep's picture
User offline. Last seen 7 hours 9 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Thanks for the quick feedback!

The scoreboard should be fixed now.

spmm's picture
User offline. Last seen 2 hours 55 min ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
No Aromatics!

A design with some distinguishing features In the side chain department would be nice for ED :) Great work fiendish.

Joined: 09/24/2012
Groups: Go Science
Interesting symmetry

There is a kind of central symmetry in this design.

Turning my solution in the cloud laterally (inverting the 2 helices) gives an almost perfect fit of the sheets (including sidechains) in the cloud.

The helices backbones fit too. Only the sidechains of the helices are not perfectly in their cloud.

The result has quite a high score. That means that the solution per se is relatively stable, and that the additional density score doesn't change much between the 2 different positions into the density cloud. It's possible that other players just have to turn their solution in order to get more points ;)

I shared the turned (second best) solution to scientists.

jeff101's picture
User offline. Last seen 15 hours 45 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
When the puzzle is over...

When Puzzle 1847 ends, please share images of both ways
in Chat for inclusion in the Foldit Wiki. It would be
interesting to see the difference and how you knew your
solution's orientation needed to be changed.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons