bkoep's picture
User offline. Last seen 12 hours 23 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue Count (max +275)
Penalizes extra residues inserted beyond the 177, at a cost of 55 points per residue. Players may use up to 182 residues in total.

Interaction Energy (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +2400)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

RockOn's picture
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Joined: 06/01/2011
Groups: Go Science
Tools: what tools are recommended to create a design?

If we can't drag the segments we work on and only the "Arrow" tool is available, how can we expect to design a protein that is useful? We will spend more of our time fighting the User Interface rather than the design. I watched jeff101 design videos, and they are now useless.

Is this intentional that the tool-set has been reduced?

bkoep's picture
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Joined: 11/15/2012
Groups: Foldit Staff
Normal tool set

All of the regular design tools should be enabled in this puzzle. Some parts of the target protein are frozen, but you should still be able to pull on any part of the designable chain.

Which tools are inaccessible for you?

Galaxie's picture
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Joined: 10/16/2011
Interaction Energy

The interaction energy bonus seems to be missing.

bkoep's picture
User offline. Last seen 12 hours 23 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Oops

Good catch! That was a mistake in my comment above.

jeff101's picture
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Joined: 04/20/2012
Groups: Go Science
Can we load results from previous puzzles?

If so, which previous puzzles' results are allowed here?

bkoep's picture
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Joined: 11/15/2012
Groups: Foldit Staff
No loading

No, solutions from previous puzzles are incompatible, so players may not load prior work.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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