puzzle picture
1831: Coronavirus Binder Design: Round 8
Status: Closed

Groups

RankGroupScorePoints
1Go Science14,882100
2Gargleblasters14,86985
3Team India14,86371
4Anthropic Dreams14,79260
5Contenders14,77949
6Beta Folders14,77341
7Void Crushers14,68733
8foldeRNA14,65227
9Hold My Beer14,48522
10Russian team14,47217
11Penny-Arcade14,41814
12Marvin's bunch14,40211
13L'Alliance Francophone14,3768
14BOINC@Poland14,3426
15Chem Eng Thermo14,1815
16FoldIt@Netherlands13,9394
17SETI.Germany13,6393
18CHNO Junkies13,4042
19Biotechnology-105 (2020)13,3532
20Rechenkraft.net13,3401
21CHEM 302/424 Spring 202012,2771
22Origami11,7801
23SOU Biochemistry CH455 (2020)11,4571
24Mojo Risin'11,1911
25Trinity Biology10,6971


Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 1 day 6 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue Count (max +275)
Penalizes extra residues inserted beyond the 177, at a cost of 55 points per residue. Players may use up to 182 residues in total.

Interaction Energy (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +2400)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

RockOn's picture
User offline. Last seen 12 weeks 7 hours ago. Offline
Joined: 06/01/2011
Groups: Go Science
Tools: what tools are recommended to create a design?

If we can't drag the segments we work on and only the "Arrow" tool is available, how can we expect to design a protein that is useful? We will spend more of our time fighting the User Interface rather than the design. I watched jeff101 design videos, and they are now useless.

Is this intentional that the tool-set has been reduced?

bkoep's picture
User offline. Last seen 1 day 6 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Normal tool set

All of the regular design tools should be enabled in this puzzle. Some parts of the target protein are frozen, but you should still be able to pull on any part of the designable chain.

Which tools are inaccessible for you?

Galaxie's picture
User offline. Last seen 44 min 51 sec ago. Offline
Joined: 10/16/2011
Interaction Energy

The interaction energy bonus seems to be missing.

bkoep's picture
User offline. Last seen 1 day 6 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Oops

Good catch! That was a mistake in my comment above.

jeff101's picture
User offline. Last seen 6 hours 13 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Can we load results from previous puzzles?

If so, which previous puzzles' results are allowed here?

bkoep's picture
User offline. Last seen 1 day 6 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
No loading

No, solutions from previous puzzles are incompatible, so players may not load prior work.

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons