Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 152, at a cost of 55 points per residue. Players may use up to 157 residues in total.
Core Existence (max +1000)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.
I think recipes would work better on puzzles like
this if the Ideal Loops Bonus depended on the total #
of residues in non-ideal loops rather than the # of
non-ideal loops. This way, shorter non-ideal loops would
score better than longer ones, and if you changed a
14-residue non-ideal loop into 2 non-ideal loops each
with length 5, your score would improve.
for more details.
Thank you so much for the suggestion--I have passed it along.
Is there value in a anti-inflammatory protein also capable of bonding to the covid spike? Obviously bonding to IL6R would take priority, but every protein has multiple angles and there may be a non intrusive way to allow one side to bond to part of the spike.
That's an interesting idea! But, in general, we prefer to have drugs that interact each with a single target. This gives doctors greater control over the treatment program. I think this would outweigh any advantages to having two functions on the same molecule (in this case, at least).
Ideally, we'd like to have one drug that targets the CoV spike, and one that targets IL6R. If a doctor decides both drugs are necessary, then they can both be administered (and hopefully there are no complex drug interactions). If the same drug targets both IL6R and CoV spike, then there is no way for a doctor to treat one without affecting the other.