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Beginner Puzzle (<150): Coronavirus
Status: Closed

Summary

Name: Beginner Puzzle (<150): Coronavirus
Status: Closed
Created: 04/15/2020
Points: 100
Expired: 05/27/2020 - 23:00
Difficulty: Intermediate
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Categories: Beginner

Top Groups

RankGroupScorePoints
1Gargleblasters13,614100
2Penny-Arcade13,47994
3Go Science13,36687
4L'Alliance Francophone13,34681
5Contenders13,31475

Top Soloists

RankPlayerGroupScorePoints
1johngran 117 368  14,008100
2ichwilldiesennamen 9 10  13,958100
3Deet 117 255  13,907100
4yuanjeff 117 298  13,770100
5bcre8tvv 117 220  13,696100


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons