1 reply [Last post]
Joined: 09/18/2010

Hi there,

I've been reading a paper on genetic variants in SARS-COV-2. The two S and L variants seem to vary
substantially in virulence and it might be helpful to get an idea why. The authors didn't seem
to have any example protein shape to go by to determine the mechanism for this.
The mutation in ORF8 leads to a change between a Serine or Leucine in the resulting protein.

The paper I mentioned can be found here.
https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25700

I thought it would make a great couple of puzzles to see the overall structure and structural changes betwen the S and L variants

With kind regards,
Bareego

Joined: 12/27/2012
Groups: Beta Folders
Now playing: ORF6

Puzzle 1817: Coronavirus ORF6 Prediction asks players to find the structure of ORF6.

Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons