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1810: Revisiting Puzzle 96: Collagen
Status: Closed

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Joined: 12/27/2012
Groups: Beta Folders
hey, collagen, man!
jeff101's picture
User offline. Last seen 12 hours 11 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Why no ppg repeats?

https://fold.it/portal/node/2008302
about poly-proline helix puzzles got
me curious about this puzzle. Isn't
collagen supposed to have 3 strands of
ppg repeats with the poly-proline helix
structure? Meanwhile, this puzzle has
one strand of 55 amino acids, just 2
prolines, and only 6 glycines. Is this
puzzle really collagen? Please explain.

neilpg628's picture
User offline. Last seen 15 hours 23 min ago. Offline
Joined: 08/01/2019
Groups: None
Collagen

You're right! This puzzle is not actually collagen, but a protein that helps make it in the human body. It is extremely important, and a lack of it has been connected to a number of muscular and connective tissue disorders. The form of collagen for the poly-proline helix puzzles is real human collagen, based on the PDB 1bkv, which does (for the most part) maintain the PPG motif.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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