puzzle picture
1808: Coronavirus Binder Design: Round 2
Status: Closed


2Go Science15,83283
4Anthropic Dreams15,82056
5Beta Folders15,79245
7Hold My Beer15,52129
8Marvin's bunch15,46723
9Void Crushers15,45818
10L'Alliance Francophone15,29014
11Hun-Magyar Csapat14,73210
13BHS - Hanks13,9206
16CHNO Junkies12,5622
17Freedom Folders11,5952
20Italiani Al Lavoro11,2971
21Mojo Risin'11,2731
22Trinity Biology11,1981
23The Daydreamers9,7951
25Minions of TWIS6,9311

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Joined: 09/24/2012
Groups: Go Science
Same objectives as before

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 192, at a cost of 55 points per residue. Players may use up to 202 residues in total.

Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

The total maximum bonus is 3950

LociOiling's picture
User offline. Last seen 1 hour 18 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
typo patrol

The line:

a new highly-infections virus

should read:

a new, highly infectious virus

I considered a second comma in there, but decided against it.

Joined: 03/04/2020
Groups: None
hello im an artist and I understand hlab27 gene has some immunit

is that your covirus protein? you have lots of sheets !
so the new challenge is to design a protien that will bind to the human site ?

Joined: 09/24/2012
Groups: Go Science

The challenge is to design a protein that will bond to the virus site (so that it cannot bind to the human site)

LociOiling's picture
User offline. Last seen 1 hour 18 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
evolver play a problem

This puzzle lets you continue work on your 1805b results, but evolver mode is a problem, since solutions load with much lower score, but evolving them still requires adding two points to the 1850b score.

For example, my 1805b solution scoring 16,534 loaded at 15,704 in 1808. But it still wants 16,536 to evo. I saw similar results in other solutions. I'm guessing that most of the evolvers are working on new solutions.

Joined: 03/11/2020
Groups: None
We Must Solve this CoronaVirus

This Coronavirus is a killer. I send my prayers to the families of the dead to this horrible disease. If one of us could crack this case, lives would be saved. As a society we must solve this. Please help everyone this needs to be solved. Nobody else should die.

jeff101's picture
User offline. Last seen 48 min 13 sec ago. Offline
Joined: 04/20/2012
Groups: Go Science
Can players load Beginner Coronavirus Puzzle solutions here?

Can players load their solutions
from the Beginner Coronavirus Puzzle
into this one?

bkoep's picture
User offline. Last seen 11 hours 3 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
No loading from Beginner Puzzle

No, solutions from the Beginner puzzle are incompatible with this puzzle. Players may not load solutions from the Beginner puzzle.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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