Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 192, at a cost of 55 points per residue. Players may use up to 202 residues in total.
Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.
The total maximum bonus is 3950
a new highly-infections virus
a new, highly infectious virus
I considered a second comma in there, but decided against it.
is that your covirus protein? you have lots of sheets !
so the new challenge is to design a protien that will bind to the human site ?
The challenge is to design a protein that will bond to the virus site (so that it cannot bind to the human site)
This puzzle lets you continue work on your 1805b results, but evolver mode is a problem, since solutions load with much lower score, but evolving them still requires adding two points to the 1850b score.
For example, my 1805b solution scoring 16,534 loaded at 15,704 in 1808. But it still wants 16,536 to evo. I saw similar results in other solutions. I'm guessing that most of the evolvers are working on new solutions.
This Coronavirus is a killer. I send my prayers to the families of the dead to this horrible disease. If one of us could crack this case, lives would be saved. As a society we must solve this. Please help everyone this needs to be solved. Nobody else should die.
Can players load their solutions
from the Beginner Coronavirus Puzzle
into this one?
No, solutions from the Beginner puzzle are incompatible with this puzzle. Players may not load solutions from the Beginner puzzle.