puzzle picture
Beginner Puzzle (<150): Coronavirus
Status: Active


Name: Beginner Puzzle (<150): Coronavirus
Status: Active
Created: 03/03/2020
Points: 100
Expires: 04/15/2020 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!


If you are new to Foldit, here are detailed instructions to get you started:

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Categories: Beginner

Top Groups

1Go Science13,833
2Italiani Al Lavoro13,491
3Beta Folders13,466
4Anthropic Dreams13,457

Top Soloists

1Wilm 89 200 Go Science13,833
2johngran 118 223  13,823
3bcre8tvv 118 1284  13,800
4Biochemica 118 837  13,739
5User3.14 118 1208  13,737

Need this puzzle? Log in to download.  


jeff101's picture
User offline. Last seen 5 hours 31 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Can players load solutions from this into Puzzles like 1808?

Can players load their solutions from this
puzzle into Coronavirus puzzles like 1808?

bkoep's picture
User offline. Last seen 11 hours 6 min ago. Offline
Joined: 11/15/2012
Groups: None
No loading into regular puzzles

The solutions from this Beginner puzzle are incompatible with other non-Beginner puzzles,. Players may not load solutions from this puzzle into other coronavirus puzzles.

Mery64's picture
User offline. Last seen 1 week 2 days ago. Offline
Joined: 03/20/2020
Groups: None
dont work

it dont works on macbook

Joined: 03/27/2020
Groups: None

try adding more hydro bonds to the virus and then mutate

Joined: 03/27/2020
Groups: None

hydro bonds to attach to the virus then mutate

Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Only search fold.it
Recommend Foldit
User login
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons