puzzle picture
1803: Aflatoxin Challenge: Round 14 Loop Prediction
Status: Closed

Summary

Name: 1803: Aflatoxin Challenge: Round 14 Loop Prediction
Status: Closed
Created: 02/20/2020
Points: 100
Expired: 02/28/2020 - 23:00
Difficulty: Intermediate
Description: Refold the loops in this Aflatoxin Challenge design! After Round 13, where Foldit players redesigned the binding loops of an oxidation enzyme, the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design! If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!

Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In the most recent phase of Foldit's Aflatoxin Challenge, the Siegel Lab at UC Davis proposed a new strategy for degrading aflatoxin, asking Foldit players to help redesign an oxidation enzyme so that it could break down aflatoxin molecules. In this puzzle, players can refold the two binding loops of the redesigned enzyme. The rest of the protein is frozen, except for some sidechains that might interact with the binding loops. No mutations or insertions are allowed. Since we are interested in how the protein might fold without aflatoxin, there is no aflatoxin molecule in the binding pocket.

This is the 14th round of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
Categories: Overall, Prediction

Top Groups

RankGroupScorePoints
1Go Science10,160100
2Contenders10,11868
3Hold My Beer10,10844
4Anthropic Dreams10,10627
5Beta Folders10,09716

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

No comments yet.
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
User login
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons